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Kiselev, I.

Publications and source records attributed to Kiselev, I..

2 recordsLinked to original sources

Real-time control of a hearing instrument with EEG-based attention decoding

Enhancing speech perception in everyday noisy acoustic environments remains an outstanding challenge for hearing aids. Speech separation technology is improving rapidly, but hearing devices cannot fully exploit this advance without knowing which sound sources the user wants to hear. Even with high-quality source separation, the hearing aid must know which speech streams to enhance and which to suppress. Advances in EEG-based decoding of auditory attention raise the potential of neurosteering, in which a hearing instrument selectively enhances the sound sources that a hearing-impaired listener is focusing their attention on. Here, we present and discuss a real-time brain-computer interface (BCI) system that combines a stimulus-response model based on canonical correlation analysis (CCA) for real-time EEG attention decoding, coupled with a multi-microphone hardware platform enabling low-latency real-time speech separation through spatial beamforming. We provide an overview of the system and its various components, discuss prospects and limitations of the technology, and illustrate its application with case studies of listeners steering acoustic feedback of competing speech streams via real-time attention decoding. A software implementation code of the system is publicly available for further research and explorations.

neuroscience↗

From miRNA target gene network to miRNA function: miR-375 might regulate apoptosis and actin dynamics in the heart muscle via Rho-GTPases-dependent pathways

MicroRNAs (miRNAs) are short single-stranded non-coding RNA molecules, which are involved in regulation of main biological processes, such as apoptosis, cell proliferation and differentiation, through sequence-specific interaction with target mRNAs. In this study we propose a workflow for predicting miRNAs function by analyzing the structure of the network of their target genes. This workflow was applied to study the functional role of miR-375 in the heart muscle (myocardium), since this miRNA was previously shown to be associated with heart diseases and data on its function in myocardium are mostly unclear. We identified PIK3CA, RHOA, MAPK3, PAFAH1B1, CTNNB1, MYC, PRKCA, ERBB2, and CDC42 as key genes in the miR-375 regulated network and predicted the possible function of miR-375 in the heart muscle, consisting mainly in the regulation of the Rho-GTPases-dependent signalling pathways. We implemented our algorithm for miRNA function prediction into Python module, which is available at GitHub (https://github.com/GJOsmak/miRNET)

bioinformatics↗