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Biology subjects

Karvanen, J.

Publications and source records attributed to Karvanen, J..

3 recordsLinked to original sources

Transporting Causal Effects in Ecology: Concepts, Models and Software

O_LIStatistical methods related to causal inference are fundamental in ecological research as ecologists often deal with causal research questions. Consequently, recent years have seen an increase in articles discussing causal inference in ecological context. However, generalizing causal findings across ecological systems that differ in environmental context still remains a challenge. While we may assess causal relationships in one location or population from experimental or observational data, replicating these findings in different settings can be impractical, expensive, or sometimes impossible. C_LIO_LIWe introduce causal effect transportability to ecological research - a formal framework for transferring causal effects assessed in one domain (the source) to estimate outcomes in different domain (the target), where broader data collection may be infeasible. Using structural causal models, this framework provides formal criteria for determining when causal effects can be validly transferred between populations and derives appropriate statistical adjustment formulas when the transportation is possible. Recent algorithmic developments, implemented in accessible R software packages, automate the mathematical derivations and make transportability analysis more practical for ecologists. C_LIO_LIWe demonstrate the framework through a case study examining the effect of tree canopy cover on dissolved oxygen concentrations across different watersheds. We succeed to show that transported estimates outperform naive applications of source population models. C_LIO_LICausal effect transportability offers critical tools for predicting ecological responses across heterogeneous settings, with particular relevance when experimental replication is constrained by cost, ethics, or urgency, and when management decisions require extrapolating findings to novel environmental contexts. C_LI

ecology↗

Physical activity is positively related to local functional connectivity in adolescents' brains

Adolescents have experienced decreased aerobic fitness levels and insufficient physical activity levels over the past decades. While both physical activity and aerobic fitness are related to physical and mental health, little is known concerning how they manifest in the brain during this stage of development, characterized by significant physical and psychosocial changes. Previous investigations have demonstrated associations of physical activity and aerobic fitness with the brains functional connectivity in both children and adults. However, it is difficult to generalize these results to adolescents because the development of functional connectivity has unique features during adolescence. Here, we examined how physical activity and aerobic fitness are associated with local and interhemispheric functional connectivity of the adolescent brain, as measured with resting-state functional magnetic resonance imaging (fMRI). Physical activity was measured by hip-worn accelerometers, and aerobic fitness by a maximal 20-m shuttle run test. We found that higher levels of moderate-to-vigorous physical activity, but not aerobic fitness, were linked to increased local functional connectivity as measured by regional homogeneity in 13-16-year-old participants. However, we did not find evidence for significant associations between adolescents physical activity or aerobic fitness and interhemispheric connectivity, as indicated by homotopic connectivity. These results suggest that physical activity, but not aerobic fitness, is related to local functional connectivity in adolescents. Moreover, physical activity shows an association with a specific brain area involved in motor functions but did not display any widespread associations with other brain regions. These results can advance our understanding of the behavior-brain associations in adolescents.

neuroscience↗

Physical activity, aerobic fitness and brain white matter: their role for executive functions in adolescence

Physical activity and exercise beneficially link to brain properties and cognitive functions in older adults, but it is unclear how these results generalise to other age groups. During adolescence, the brain undergoes significant changes, which are especially pronounced in white matter. Existing studies provide contradictory evidence regarding the influence of physical activity or aerobic-exercise on executive functions in youth. Little is also known about the link between both aerobic fitness and physical activity with white matter during puberty. For this reason, we investigated the connection between both aerobic fitness (20-m shuttle run) and physical activity (moderate-to-vigorous intensity physical activity) with white matter in 59 adolescents (12.7-16.2 years). We further determined whether white matter interacts with the connection of fitness or physical activity with three core executive functions (sustained attention, spatial working memory and response inhibition). Our results showed that only the level of aerobic fitness, but not of physical activity was related to white matter properties. Furthermore, the white matter of specific tracts also moderated the links of aerobic fitness and physical activity with working memory. Our results suggest that aerobic fitness and physical activity have an unequal contribution to the properties of white matter in adolescent brains. We propose that the differences in white matter properties could underlie the variations in the relationship between either physical activity or aerobic fitness with working memory.\n\nHighlightsO_LIAerobic fitness level, but not physical activity, is associated with white matter properties in several white matter tracts in the brain.\nC_LIO_LIThe relationship between aerobic fitness and working memory was moderated by fractional anisotropy of the body of corpus callosum and in the right superior corona radiata.\nC_LIO_LIThe relationship between physical activity and working memory was moderated by fractional anisotropy of the body and genu of corpus callosum.\nC_LI

neuroscience↗