Biology subjects

Jurewicz, K.

Publications and source records attributed to Jurewicz, K..

4 recordsLinked to original sources

bioRxiv2025

Common but different: An ERP study of single- and multi-source interference processing in MSIT

Flexible behavior often requires processing of complex, interfering information. Research has investigated conflict-related brain processes mostly using single tasks which hindered direct comparison of different interference types. Thus, the question if they are resolved by a common mechanism or by a set of different, task-specific mechanisms remains open. In this study, we used event-related potentials (ERPs) to examine the spatio-temporal dynamics of cognitive control across Simon, flanker, multi-source and no-conflict conditions. Our findings reveal that all trial types engaged the same sequence of processing stages, as indicated by common ERP waveforms and consistent number and order of microstates across conditions. However, the intensity and duration of these common stages scaled with difficulty of the conflict task (as measured by RTs and accuracy) from Simon to flanker to multi-source interference. Flanker conflict uniquely influenced early ERP components strongly engaging the dorsal attentional system and visual areas, likely due to demands posed by the presence of flanker distractors. Later ERP components (with sources including ventral attention and somatomotor network areas) were affected by both conflicts. Accordingly, when flanker and Simon conflicts were presented together, early processes lineary summed up, but there was an interaction at the later stage of processing paralleling nonlinear drop of accuracy in a multi-conflict condition. Our study provides novel insights into the neural dynamics underlying cognitive control engaged across different conflict types and their interaction. The use of source analysis allowed us to ground ERP-based findings in the wider context of studies, including those using neuroimaging techniques. Highlights- The same processing stages, in same order are evoked in control and conflict trials - Their intensity/duration scale with conflict behavioral difficulty - Flanker conflict demands enhanced early attentional (DAN) and visual processing - Flanker and Simon interact at the late-stage processing involving VAN and SM networks - Flanker and Simon interaction is sublinear

neuroscience↗

bioRxiv2023

Pupil size predicts the onset of exploration in brain and behavior.

In uncertain environments, intelligent decision-makers exploit actions that have been rewarding in the past, but also explore actions that could be even better. Several neuromodulatory systems are implicated in exploration, based, in part, on work linking exploration to pupil size-a peripheral correlate of neuromodulatory tone and index of arousal. However, pupil size could instead track variables that make exploration more likely, like volatility or reward, without directly predicting either exploration or its neural bases. Here, we simultaneously measured pupil size, exploration, and neural population activity in the prefrontal cortex while two rhesus macaques explored and exploited in a dynamic environment. We found that pupil size under constant luminance specifically predicted the onset of exploration, the first exploratory trial in a sequence, beyond what could be explained by reward history. Pupil size also predicted disorganized patterns of prefrontal neural activity at both the single neuron and population levels, even within periods of exploitation. Ultimately, our results support a model in which pupil-linked mechanisms promote the onset of exploration via driving the prefrontal cortex through a critical tipping point where prefrontal control dynamics become disorganized and exploratory decisions are possible. Significance StatementHumans and other animals learn about the world through exploration: through making decisions that offer the opportunity to learn and discover, even when these decisions are not the best option in the moment. Neuroscience research has historically focused on understanding good choices, delivering many key insights into the neural mechanisms involved in these calculations. However, much less is known about how the brain generates exploratory decisions. This study identifies certain "early warning signs" of exploratory decisions in the brain and body, including certain signals in size of the pupil and the speed of neural activity in the prefrontal cortex. These early warning signs suggest that exploration may be the result of a critical tipping point in prefrontal brain states.

neuroscience↗

bioRxiv2023

Common and distinct BOLD correlates of Simon and flanker conflicts which can(not) be reduced to time-on-task effects

The ability to identify and resolve conflicts between standard, well trained behaviors, and behaviors required by the current context is an essential feature of cognitive control. To date, no consensus has been reached on the brain mechanisms involved in exerting such control: while some studies identified diverse patterns of activity across different conflicts, other studies reported common resources across conflict tasks or even across simple tasks devoid of conflict component. The latter reports attributed the entire activity observed in the presence of conflict to longer time spent on the task (i.e. to the so-called time-on-task effects). Here we used an extended Multi-Source Interference Task (MSIT) which combines Simon and flanker types of interference to determine shared and conflict-specific mechanisms of conflict resolution in fMRI, and their separability from the time-on-task effects. Large portions of the activity in the dorsal attention network and decreases of activity in the default mode network were shared across the tasks and scaled in parallel with increasing reaction times. Importantly, activity in the sensory and sensorimotor cortices, as well as in the posterior medial frontal cortex (pMFC)-a key region implicated in conflict processing-could not be exhaustively explained by the time-on-task effects.

neuroscience↗

bioRxiv2022

Irrational choices via a curvilinear representational geometry for value

We make decisions by comparing values, but how is value represented in the brain? Many models assume, if only implicitly, that the representational geometry of value is linear. However, in part due to a historical focus on noisy single neurons, rather than neuronal populations, this hypothesis has not been rigorously tested. Here, we examined the representational geometry of value in the ventromedial prefrontal cortex (vmPFC), a part of the brain linked to economic decision-making. We found that values were encoded along a curved manifold in vmPFC. This curvilinear geometry predicted a specific pattern of irrational decision-making: that decision-makers will make worse choices when an irrelevant, decoy option is worse in value, compared to when it is better. Indeed, we observed these irrational choices in behavior. Together, these results not only suggest that the representational geometry of value is nonlinear, but that this nonlinearity could impose bounds on rational decision-making.

neuroscience↗