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Biology subjects

Jonsson, B. G.

Publications and source records attributed to Jonsson, B. G..

2 recordsLinked to original sources

Mapping forests with different levels of naturalness using machine learning and landscape data mining

To conserve biodiversity, it is imperative to maintain and restore sufficient amounts of functional habitat networks. Hence, locating remaining forests with natural structures and processes over landscapes and large regions is a key task. We integrated machine learning (Random Forest) and open landscape data to scan all forest landscapes in Sweden with a 1 ha spatial resolution with respect to the relative likelihood of hosting High Conservation Value Forests (HCVF). Using independent spatial stand-and plot-level validation data we confirmed that our predictions (ROC AUC in the range of 0.89 - 0.90) correctly represent forests with different levels of naturalness, from deteriorated to those with high and associated biodiversity conservation values. Given ambitious national and international conservation objectives, and increasingly intensive forestry, our model and the resulting wall-to-wall mapping fills an urgent gap for assessing fulfilment of evidence-based conservation targets, spatial planning, and designing forest landscape restoration.

ecology↗

A genome-wide association study of serum proteins reveals shared loci with common diseases

With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with genetic variants offers a path to deeper functional insights. Here we present a large-scale proteogenomic study in 5,368 individuals, revealing 4,113 independent associations between genetic variants and 2,099 serum proteins, of which 37% are previously unreported. The majority of both cis- and trans-acting genetic signals are unique for a single protein, although our results also highlight numerous highly pleiotropic genetic effects on protein levels and demonstrate that a proteins genetic association profile reflects certain characteristics of the protein, including its location in protein networks, tissue specificity and intolerance to loss of function mutations. Integrating protein measurements with deep phenotyping of the cohort, we observe substantial enrichment of phenotype associations for serum proteins regulated by established GWAS loci, and offer new insights into the interplay between genetics, serum protein levels and complex disease.

genomics↗