Jasmin, K. | Search bioRxiv

bioRxiv2018

Overt social interaction and resting state in autism: core and contextual neural features

Conversation is an important and ubiquitous social behavior. Individuals with Autism Spectrum Disorder (autism) without intellectual disability often have normal structural language abilities but deficits in social aspects of communication like pragmatics, prosody, and eye contact. Previous studies of resting state activity suggest that intrinsic connections among neural circuits involved with social processing are disrupted in autism, but to date no neuroimaging study has examined neural activity during the most commonplace yet challenging social task: spontaneous conversation. Here we used functional MRI to scan autistic males (N=19) without intellectual disability and age- and IQ-matched typically developing controls (N=20) while they engaged in a total of 193 face-to-face interactions. Participants completed two kinds of tasks: Conversation, which had high social demand, and Repetition, which had low social demand. Autistic individuals showed abnormally increased task-driven inter-regional temporal correlation relative to controls, especially among social processing regions and during high social demand. Furthermore, these increased correlations were associated with parent ratings of participants social impairments. These results were then compared with previously-acquired resting-state data (56 Autism, 62 Control participants). While some inter-regional correlation levels varied by task or rest context, others were strikingly similar across both task and rest, namely increased correlation among the thalamus, dorsal and ventral striatum, somatomotor, temporal and prefrontal cortex in the autistic individuals, relative to the control groups. These results suggest a basic distinction. Autistic cortico-cortical interactions vary by context, tending to increase relative to controls during Task and decrease during Rest. In contrast, striato- and thalamocortical relationships with socially engaged brain regions are increased in both Task and Rest, and may be core to the condition of autism.

neuroscience↗

bioRxiv2018

Redundancy makes music and speech robust to individual differences in perception

In speech, linguistic information is conveyed redundantly by many simultaneously present acoustic dimensions, such as fundamental frequency, duration and amplitude. Listeners show stable tendencies to prioritize these acoustic dimensions differently, relative to one another, which suggests individualized speech perception strategies. However, it is unclear what drives these strategies, and more importantly, what impact they have on diverse aspects of communication. Here we show that such individualized perceptual strategies can be related to individual differences in perceptual ability. In a cue weighting experiment, we first demonstrate that individuals with a severe pitch perception deficit (congenital amusics) categorize linguistic stimuli similarly to controls when their deficit is unrelated to the main distinguishing cue for that category (in this case, durational or temporal cues). In contrast, in a prosodic task where pitch-related cues are typically more informative, amusics place less importance on this pitch-related information when categorizing speech. Instead, they relied more on duration information. Crucially, these differences in perceptual weights were observed even when pitch-related differences were large enough to be perceptually distinct to amusic listeners. In a second set of experiments involving musical and prosodic phrase interpretation, we found that this reliance on duration information allowed amusics to overcome their perceptual deficits and perceive both speech and music successfully. These results suggest that successful speech - and potentially music - comprehension is achieved through multiple perceptual strategies whose underlying weights may in part reflect individuals perceptual abilities.

neuroscience↗