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Biology subjects

Jankowski, J.

Publications and source records attributed to Jankowski, J..

2 recordsLinked to original sources

Predicting Bird Distributions Under Global Change

An introduction to predictive distribution modelling for conservation to encourage novel perspectives. The rapid pace and potentially irreversible consequences of global change create an urgent need to predict the spatial responses of biota for conservation to better inform the prioritization and management of terrestrial habitats and prevent future extinctions. Here, we provide an accessible entry point to the field to guide near-future work building predictive species distribution models (SDMs) by synthesizing a technical framework for the proactive conservation of avian biodiversity. Our framework offers a useful approach to navigate the challenges surrounding the large spatio-temporal resolution of datasets and datasets that favor hypothesis testing at broad spatio-temporal scales and coarse resolutions, which can affect our ability to assess the validity of current predicted distributions. We explain how to improve the accuracy of predictive models by determining the extent to which: 1) dispersal limitation impacts the rate of range shifts, 2) taxa are rare at their range limits, and 3) land use and climate change interact. Finally, we offer approaches to filling knowledge gaps by creatively leveraging existing methods and data sources. RESUMENUna introduccion a la modelizacion predictiva de la distribucion para la conservacion con el fin de fomentar nuevas perspectivas. El rapido ritmo y las consecuencias potencialmente irreversibles del cambio global crean una necesidad urgente de predecir las respuestas espaciales de la biota para la conservacion, con el fin de informar mejor la priorizacion y gestion de los habitats terrestres y prevenir futuras extinciones. Aqui proporcionamos un punto de entrada accesible al campo para guiar el trabajo del futuro proximo en la construccion de modelos predictivos de distribucion de especies (SDM), sintetizando un marco tecnico para la conservacion proactiva de la biodiversidad aviar. Nuestro marco ofrece un enfoque util para navegar por los retos que rodean a la gran resolucion espacio-temporal de los conjuntos de datos y a los conjuntos de datos que favorecen la comprobacion de hipotesis a escalas espacio-temporales amplias y resoluciones gruesas, lo que puede afectar a nuestra capacidad para evaluar la validez de las distribuciones predichas actuales. Explicamos como mejorar la precision de los modelos predictivos determinando hasta que punto 1) la limitacion de la dispersion influye en el ritmo de los cambios de area de distribucion, 2) los taxones son raros en los limites de su area de distribucion, y 3) el uso del suelo y el cambio climatico interactuan. Por ultimo, proponemos enfoques para colmar las lagunas de conocimiento aprovechando de forma creativa los metodos y fuentes de datos existentes.

ecology↗

Interferon-regulated genetic programs and JAK/STAT pathway activate the intronic promoter of the short ACE2 isoform in renal proximal tubules

Recently, a short, interferon-inducible isoform of Angiotensin-Converting Enzyme 2 (ACE2), dACE2 was identified. ACE2 is a SARS-Cov-2 receptor and changes in its renal expression have been linked to several human nephropathies. These changes were never analyzed in context of dACE2, as its expression was not investigated in the kidney. We used Human Primary Proximal Tubule (HPPT) cells to show genome-wide gene expression patterns after cytokine stimulation, with emphasis on the ACE2/dACE2 locus. Putative regulatory elements controlling dACE2 expression were identified using ChIP-seq and RNA-seq. qRT-PCR differentiating between ACE2 and dACE2 revealed 300- and 600-fold upregulation of dACE2 by IFN and IFN{beta}, respectively, while full length ACE2 expression was almost unchanged. JAK inhibitor ruxolitinib ablated STAT1 and dACE2 expression after interferon treatment. Finally, with RNA-seq, we identified a set of genes, largely immune-related, induced by cytokine treatment. These gene expression profiles provide new insights into cytokine response of proximal tubule cells.

genomics↗