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Huys, Q. J.

Publications and source records attributed to Huys, Q. J..

2 recordsLinked to original sources

Sense of control buffers against stress

Stress is one of the most pervasive causes of mental ill-health across the lifespan. Subjective dimensions of stress perception, such as perceived control, are especially potent in shaping stress responses. While the impact of reduced or no control over stress is well understood, much less is known about whether heightened feelings of control buffer against the negative impact of later stress. We designed a novel paradigm with excellent psychometric properties to sensitively capture and induce different states of subjective control. Across two studies with a non-clinical sample of 768 adults, we show a robust association between sense of control and stress as well as symptoms of mental ill-health. More importantly, in a subsample of 295 participants we show that compared to a neutral control group, inducing a heightened state of subjective control buffers against the impact of later stress. These findings demonstrate a causal role for a heightened sense of control in mitigating the negative impact of stressful experiences and spell out important directions for future preventative interventions.

neuroscience↗

Emotion-induced frontal α asymmetry predictsrelapse after discontinuation of antidepressantmedication

AO_SCPLOWBSTRACTC_SCPLOWO_ST_ABSBackgroundC_ST_ABSOne in three patients relapse after antidepressant discontinuation. Thus, the prevention of relapse after achieving remission is an important component in the long-term management of Major Depressive Disorder (MDD). However, no clinical or other predictors are established. Frontal reactivity to sad mood as measured by fMRI has been reported to relate to relapse independently of antidepressant discontinuation and is an interesting candidate predictor. MethodsPatients (n=56) who had remitted from a depressive episode while taking antidepressants underwent EEG recording during a sad mood induction procedure prior to gradually discontinuing their medication. Relapse was assessed over a six-months follow-up period. 35 healthy controls were also tested. Current source density of the EEG power in the band (8-13Hz) was extracted and alpha-asymmetry was computed by comparing the power across two hemispheres at frontal electrodes (F5 and F6). OutcomesSad mood induction was robust across all groups. Reactivity of -asymmetry to sad mood did not distinguish healthy controls from patients with remitted MDD on medication. However, the 14 (25%) patients who relapsed during the follow-up period after discontinuing medication showed significantly reduced reactivity in -asymmetry compared to patients who remained well. This EEG signal provided predictive power (69% out-of-sample balanced accuracy). InterpretationA simple EEG-based measure of emotional reactivity may have clinical utility in the management of antidepressant discontinuation. FundingSwiss National Science Foundation project grant 320030L_153449 / 1 to QJMH, Stiftung Deutsche Depressionshilfe to HW and QJMH, a Deutsche Forschungsgemeinschaft (DFG) grant (WA 1539/5-1) to HW, EMDO Stiftung to QJMH and the Rene and Susanne Braginsky Foundation and Clinical Research Priority Programme "Molecular Imaging" at the University of Zurich to KES.

neuroscience↗