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Hoffman, P.

Publications and source records attributed to Hoffman, P..

At least 19 recordsLinked to original sources

Specialized Computations for Generalized World Modelling in Medial Prefrontal Cortex

The medial prefrontal cortex is central to learning flexible internal models across diverse domains, yet the functional specialization enabling this remains unknown. We tested whether medial prefrontal specialization is representational (encoding domain-specific features) or computational (implementing domain-general computations). During fMRI, participants learned probabilistic features of virtual environments representing spatial, social, and sequential domain knowledge. Although each domain used different features, they shared the same feature-to-latent state mapping, matching their computational demands. The medial PFC showed no domain-specific feature representations. Instead, its neural patterns revealed a triad of specialized yet domain-invariant computations. Ventromedial PFC patterns reflected probabilistic inference, abstracting hidden probability distributions from observations and tracking trial-wise posterior task state changes within a low-dimensional latent space. Anteromedial PFC organized task states along orthogonal axes, tracking directional shifts within states and switches between different states, suggesting a global task coordinate system. Dorsomedial PFC patterns represented task dynamics, using predictive surprise to monitor validity of the current internal model and switch task policies. These results suggest a principled architecture in medial PFC where three general-purpose computations jointly enable learning world-models across diverse environments.

neuroscience↗

Polycyclic aromatic hydrocarbons, gut microbiome composition, impulsivity, and attention covary in a human cohort

Polycyclic aromatic hydrocarbons (PAHs) are pervasive environmental pollutants linked to adverse neurobehavioral outcomes, yet the biological pathways coupling exposure to behavior are poorly defined. The gut microbiome is both sensitive to PAH exposure and a modulator of central nervous system function, suggesting it may mediate how PAH exposure influences neurobehavior. We tested whether PAH exposure, gut microbiome composition, and neurobehavioral function covary in a statewide sample of 34 adults stratified into high-impulsivity/poor-attention (HH) and low-impulsivity/fast-attention (LL) groups. Participants provided fecal samples for 16S rRNA profiling and wore silicone wristbands for 30 days to passively sample PAH exposure. Higher PAH exposure associated with HH group membership in a sex-dependent manner, with the largest elevations among HH males. At the community level, PAH exposure profiles correlated with microbiome dissimilarity, and HH membership associated with increased alpha-diversity and altered community composition relative to LL members. At the taxon level, 21 genera were significantly associated with 14 PAH compounds (FDR < 0.1). No individual genera were significantly associated with neurobehavioral group after multiple testing correction. Nevertheless, cross-referencing PAH-responsive genera (FDR < 0.1) against those with nominal neurobehavioral associations (p < 0.05) identified two candidate genera, Hydrogenoanaerobacterium and Methanobrevibacter, whose abundance covaries with both PAH exposure and neurobehavioral phenotype. Both have been independently linked to cognitive or neurological outcomes in prior work. These findings support a three-way relationship among environmental chemical exposure, gut microbiome composition, and neurobehavioral function, establishing an empirical foundation for testing microbiome-mediated links between PAH exposure and neurobehavioral outcomes. IMPORTANCEPAH exposure is widespread and associates with impulsivity and attention problems, but how exposure translates into neurobehavioral risk is unclear. The gut microbiome is a plausible intermediary: gut microbes biotransform environmental chemicals and produce metabolites that influence brain function. In a statewide adult cohort, we show that higher PAH exposure tracks with greater impulsivity and poorer attention in a sex-dependent manner, and that both PAH exposure and neurobehavioral phenotype associate with distinct gut microbiome features at the community and taxon levels. We identify candidate genera at the intersection of PAH exposure and neurobehavioral group whose biology independently implicates them in cognitive and neurological function. By demonstrating that all three domains covary within a single human cohort, this work moves beyond pairwise associations to identify candidate microbial intermediaries for mechanistic investigation. Defining the microbiome constituents that respond to PAH exposure and co-associate with neurobehavioral phenotypes creates opportunities to test microbiome-targeted or exposure-reduction strategies for mitigating PAH-related neurobehavioral impacts.

microbiology↗

Subclinical anxiety is associated with reduced self-distancing and enhanced guilt-related connectivity between anterior temporal and subgenual cingulate cortices

Excessive self-blaming emotions are commonly observed in anxiety disorders, with qualitatively similar symptomatology reported in subclinical populations. Interpretation of moral information requires assessing the social conceptual information, a process overseen by the superior anterior temporal lobe (sATL). Feelings of self-blame evoke interactions of sATL and socio-affective regions, and previous research shows that subclinical anxiety modulates the organisation of the self-blame circuitry. This study aimed to extend these findings by exploring links of trait-anxiety with (i) self-blaming emotions and associated behaviours in an experimental task, and (ii) self-blame-dependent neural activity and connectivity, as observed during reliving of autobiographical guilt memories. We also explored the role of resting-state fMRI in linking these phenomena. Increased anxiety was linked to stronger self-blaming emotions, and more pronounced self-attacking and hiding. When experiencing negative emotions about themselves (i.e. shame and self-anger), anxious individuals were also less likely to disengage from self-focused thoughts. These behavioural findings were paralleled by enhanced self-blame-related connectivity between the left sATL and bilateral posterior subgenual cingulate cortex. Distinct patterns of activity and connectivity within the ATL-related circuitry were furthermore linked to individual differences in intensity of the self-blaming emotions and approach-avoidance motivation towards the guilt memories. As such, the results of the current study link stronger self-blaming emotions in anxious individuals with specific maladaptive patterns of behaviour. Furthermore, the work provides robust evidence for the important role of ATL-related circuitry in self-blame processing, supporting its broader involvement in social conceptual processing and its alterations in subclinical anxiety.

neuroscience↗

Balancing Act: A Neural Trade-Off Between Coherence and Creativity in Spontaneous Speech

Effective communication involves a delicate balance between generating novel, engaging content and maintaining a coherent narrative. The neural mechanisms underlying this balance between coherence and creativity in discourse production remain unexplored. The aim of the current study was to investigate the relationship between coherence and creativity in spontaneous speech, with a specific focus on the interaction among three key neural networks: the Default Mode Network, Multiple Demand Network, and the Semantic Control Network. To this end, we conducted a two-part analysis. At the behavioural level, we analysed speech samples produced in response to topic cues, computing measures of global coherence (indexing the degree of connectedness to the main topic) and Divergent Semantic Integration (DSI; reflecting the diversity of ideas incorporated in the narrative). Coherence and divergence in speech were negatively correlated, suggesting a trade-off between maintaining a coherent narrative structure and incorporating creative elements. At the neural level, higher global coherence was associated with greater activation in the Multiple Demand Network, emphasising its role in organising and sustaining logical flow in discourse production. In contrast, functional connectivity analyses demonstrated that higher DSI was related to greater coupling between the Default Mode and Multiple Demand Networks, suggesting that creative speech relies on a dynamic interplay between associative and executive processes. These results provide new insights into the cognitive and neural processes underpinning spontaneous speech production, highlighting the complex interplay between different brain networks in managing competing demands of being coherent and creative.

neuroscience↗

Fragmentation and Multithreading of Experience in the Default-Mode Network

Reliance on internal predictive models of the world is central to many theories of human cognition. Yet it is unknown whether humans acquired multiple separate internal models, each evolved for a specific domain, or maintain a globally unified representation. Using fMRI during naturalistic experiences (movie watching and narrative listening), we show that three topographically distinct midline prefrontal cortical regions perform distinct predictive operations. The ventromedial PFC updates contextual predictions (States), the anteromedial PFC governs reference frame shifts for social predictions (Agents), and the dorsomedial PFC predicts transitions across the abstract state spaces (Actions). Prediction-error-driven neural transitions in these regions, indicative of model updates, coincided with subjective belief changes in a domain-specific manner. We find these parallel top-down predictions are unified and selectively integrated with sensory streams in the Precuneus, shaping participants ongoing experience. Results generalized across sensory modalities and content, suggesting humans recruit abstract, modular predictive models for both vision and language. Our results highlight a key feature of human world modeling: fragmenting information into abstract domains before global integration.

neuroscience↗

Effect of Voltage-Gated K+ Channel Inhibition by 4-aminopyridine in Spinal Cord Injury Recovery in Zebrafish

Spinal cord injury (SCI) affects 250,000 to 500,000 individuals annually. After the initial injury, a delayed secondary cascade of cellular responses occurs causing progressive degeneration and permanent disability. One part of this secondary process is disturbance of ionic homeostasis. The K+ channel blocker, 4-aminopyridine (4-AP), is used clinically to alleviate symptoms of multiple sclerosis (MS). Several ongoing studies are being conducted to explore additional areas where 4-AP may have an effect, including stroke, traumatic brain injury, and nervous system recovery after SCI. The goal of our study was to determine whether 4-AP affects functional recovery from SCI in zebrafish (Danio rerio). Using the transgenic line Tg(gfap:EGFP; elavl3:mCherry-CAAX), we created a spinal transection, tracked swim recovery, and measured 4-AP toxicity. We found that constant treatment with 10 M 4-AP increases swimming distance 40%. Live imaging demonstrated that treatment with 4-AP did not accelerate axonal bridging but did affect radial glial cells suggesting that 4-AP affects functional recovery through mechanisms other than axon regeneration. Higher concentrations provided no additional functional benefit and led to increased toxicity in zebrafish.

pharmacology and toxicology↗

Neural specialisation for concrete and abstract concepts revealed through meta-analysis

Identifying the brain regions that process concrete and abstract concepts is key to understanding the neural architecture of thought, memory and language. We review current theories of concreteness effects and test their neural predictions in a meta-analysis of 72 neuroimaging studies (1400 participants). Our analysis includes more than twice as many studies as previous meta-analyses, allowing for a more sensitive mapping of these effects across the brain. We also conducted a quantitative assessment of the degree to which concreteness effects aligned with a range of large-scale functional brain networks. Our results suggest that concrete and abstract concepts vary both in the information-processing modalities they engage and in the demands they place on cognitive control processes. Abstract concepts preferentially activated networks for social cognition (particularly for sentences), language and semantic control (particularly when presented as single words). Concrete concepts preferentially activated action processing regions when presented in sentences, though we found no evidence that they activated visual networks. Specialisation for both concept types was present in different parts of the default mode network (DMN), with effects dissociating along a social-spatial axis. Concrete concepts generated greater activation in a medial temporal DMN component, implicated in constructing mental models of spatial contexts and scenes. In contrast, abstract concepts showed greater activation in frontotemporal DMN regions involved in social and language processing. These results align with prior claims that generating models of situations and events is a core DMN function and indicate specialisation within DMN for different aspects of these models.

neuroscience↗

Verbal semantic expertise is associated with reduced functional connectivity between left and right anterior temporal lobes

The left and right anterior temporal lobes (ATLs) encode semantic representations. They show graded hemispheric specialisation in function, with the left ATL contributing preferentially to verbal semantic processing. We investigated the underlying causes of this organisation, using resting-state functional connectivity as a measure of functional segregation between ATLs. We analysed two independent resting-state fMRI datasets (N=86 and N=642) in which participants verbal semantic expertise was measured using vocabulary tests. In both datasets, people with more advanced verbal semantic knowledge showed weaker functional connectivity between left and right ventral ATLs. This effect was highly specific. It was not observed for within-hemisphere connections between semantic regions (ventral ATL and inferior frontal gyrus; IFG, though it was found for left-right IFG connectivity in one dataset). Effects were not found for tasks probing semantic control, non-semantic cognition or face recognition. Our results suggest that hemispheric specialisation in the ATLs is not an innate property but rather emerges as people develop highly detailed verbal semantic representations. We propose that this effect is a consequence of the left ATLs greater connectivity with left-lateralised written word recognition regions, which causes it to preferentially represent meaning for advanced vocabulary acquired primarily through reading.

neuroscience↗

Functional integration and segregation during semantic cognition: Evidence across age groups

Semantic cognition is underpinned by ventral anterior temporal lobe (vATL) which encodes knowledge representations and inferior frontal gyri (IFG), which controls activation of knowledge based on the needs of the current context. This core semantic network has been validated in substantial empirical findings in the past. However, it remains unclear how these core semantic areas dynamically communicate with each other to achieve successful semantic processing. Here, we investigated this question by testing functional connectivity in the core semantic network during semantic tasks and whether these connections were affected by cognitive ageing. Compared to a non-semantic executive task, semantic tasks increased the connectivity between left and right IFGs, indicating a bilateral semantic control system. Strengthened connectivity was also found between left IFG and left vATL, and this effect was stronger in the young group. At a whole-brain scale, IFG and vATL increased their coupling with multiple-demand regions during semantic tasks, even though these areas were deactivated relative to non-semantic tasks. This suggests that the domain- general executive network contributes to semantic processing. In contrast, IFG and vATL decreased their interaction with default mode network (DMN) areas during semantic tasks, even though these areas were positively activated by the task. This suggests that DMN areas do not contribute to all semantic tasks: their activation may sometimes reflect automatic retrieval of task-irrelevant memories and associations. Taken together, our study characterized a dynamic connectivity mechanism supporting semantic cognition within and beyond core semantic regions.

neuroscience↗

Representation of event and object concepts in ventral anterior temporal lobe and angular gyrus

Semantic knowledge includes understanding of objects and their features and also understanding of the characteristics of events. The hub-and-spoke theory holds that these conceptual representations rely on multiple information sources that are integrated in a central hub in the ventral anterior temporal lobes (vATL). Dual-hub theory expands this framework with the claim that the vATL hub is specialized for object representation, while a second hub in angular gyrus (AG) is specialized for event representation. To test these ideas, we used RSA, univariate and PPI analyses of fMRI data collected while participants processed object and event concepts (e.g., an apple, a wedding) presented as images and written words. RSA showed that AG encoded event concept similarity more than object similarity, although the left AG also encoded object similarity. Bilateral vATLs encoded both object and event concept structure, and left vATL exhibited stronger coding for events. PPI analysis revealed greater connectivity between left vATL and right pMTG, and between right AG and bilateral ITG and middle occipital gyrus, for event concepts compared to object concepts. These findings support the specialization of AG for event semantics, though with some involvement in object coding, but do not support vATL specialization for object concepts.

neuroscience↗

Distinctive and complementary roles of default mode network subsystems in semantic cognition

The default mode network (DMN) typically deactivates to external tasks, yet supports semantic cognition. It comprises medial temporal (MT), core, and fronto-temporal (FT) subsystems, but its functional organisation is unclear: the requirement for perceptual coupling versus decoupling, input modality (visual/verbal), type of information (social/spatial) and control demands all potentially affect its recruitment. We examined the effect of these factors on activation and deactivation of DMN subsystems during semantic cognition, across four task-based functional magnetic resonance imaging (fMRI) datasets, and localised these responses in whole-brain state space defined by gradients of intrinsic connectivity. FT showed activation consistent with a central role across domains, tasks and modalities, although it was most responsive to abstract, verbal tasks; this subsystem uniquely showed more tuned states characterised by increases in both activation and deactivation when semantic retrieval demands were higher. MT also activated to both perceptually-coupled (scenes) and decoupled (autobiographical memory) tasks, and showed stronger responses to picture associations, consistent with a role in scene construction. Core DMN consistently showed deactivation, especially to externally-oriented tasks. These diverse contributions of DMN subsystems to semantic cognition were related to their location on intrinsic connectivity gradients: activation was closer to sensory-motor cortex than deactivation, particularly for FT and MT, while activation for core DMN was distant from both visual cortex and cognitive control. These results reveal distinctive yet complementary DMN responses: MT and FT support different memory-based representations that are accessed externally and internally, while deactivation in core DMN is associated with demanding, external semantic tasks. Significance StatementWe delineate the functional organisation of DMN in semantic cognition, examining effects of perceptual coupling versus decoupling, input modality (visual/verbal), domain (social/spatial) and control demands across DMN subsystems in four fMRI datasets. These subsystems played complementary roles in semantic cognition related to their locations on gradients of intrinsic connectivity. Medial temporal and frontotemporal subsystems supported visuospatial and abstract conceptual information respectively, across both internally and externally-focussed tasks, while deactivation in core DMN was associated with focussed and externally-oriented semantic states. We conclude that both content and process are relevant to the functional architecture of DMN in semantic cognition.

neuroscience↗

Age-related changes in the neural processing of semantics, within and beyond the core semantic network

Ageing is associated with increases in functional activation, which have been interpreted either as compensatory responses to the higher task demands older people experience, or as neural dedifferentiation. Ageing is also characterised by a shift to greater reliance on prior knowledge and less on executive function, whose underlying neural mechanism is poorly understood. This pre-registered fMRI study investigated these questions within the domain of semantic cognition. To disentangle the compensation and dedifferentiation theories, we extracted activation signal in core verbal semantic regions, for young and older participants during semantic tasks. Verbal semantic processing relies heavily on left inferior frontal gyrus (IFG) but older people frequently show additional right IFG activation. We found that right IFG exhibited a similar linear activation-demand relationship as left IFG across age groups and semantic tasks, indicating that age-related over-recruitment of this region may be compensatory in nature. To answer the second question, we examined network-level activity and connectivity changes in semantic and non-semantic tasks. Older people showed more engagement of the default mode network (DMN) and less of the executive multiple demand network (MDN) aligning with their greater reserves of prior knowledge and declined executive control. In contrast, activation was age-invariant in regions contributing specifically to executive control of semantic processing. Older adults also showed a degraded ability to modulate MDN activation as a function of demand in the non-semantic task, but not in the semantic tasks. These findings provide a new perspective on the neural basis of semantic cognition in later life, and suggest that preservation of activation in specialised semantic networks may support preserved performance in this critical domain.

neuroscience↗

Developmental Characterization of Neuronal Migration Anomalies and Axon Proliferation in mTOR pathway-associated Malformations of Cortical Development

Drug-resistant epilepsy (DRE) is a prevalent problem in children that can lead to abnormal development and various psychiatric comorbidities. Malformations of cortical development (MCD) include focal cortical dysplasia, tuberous sclerosis complex and hemimegalencephaly, which are the most common pathologies among children who undergo surgical resection for treatment of DRE. These disorders share many histopathological features, including dyslamination of the cerebral cortex and enlarged neuronal somata. Recently, genetic mutations in the mammalian target of rapamycin (mTOR) signaling cascade have been shown to underpin most MCDs. Rodent models, including the RhebCA model, recapitulate histologic and physiologic aspects of human DRE. However, there have been few studies characterizing the developmental time point of the histological changes seen in MCDs. In this study, we use in utero electroporation to upregulate the Rheb protein (directly upstream of mTOR) in a focal area of the neocortex. We demonstrate that mTOR dysregulation leads to focal dyslamination and increased neuronal size that is histologically similar to MCD, which correlates to spontaneous recurrent seizures. We used immunohistochemistry to investigate neuronal lamination at several time points during development between E18 and P21 and show early differences in lamination that persisted through development. Furthermore, the increased axonal length associated with mTOR upregulation occurs early in development. Our study provides a time frame for the initial development of abnormal neuronal migration and cellular growth that occurs in MCDs, and our data supports that these anatomical changes may contribute to the formation of epileptic networks.

neuroscience↗

A common neural code for meaning in discourse production and comprehension

How does the brain code the meanings conveyed by language? Neuroimaging studies have investigated this by linking neural activity patterns during discourse comprehension to semantic models of language content. Here, we applied this approach to the production of discourse for the first time. Participants underwent fMRI while producing and listening to discourse on a range of topics. We used a distributional semantic model to quantify the similarity between different speech passages and identified where similarity in neural activity was predicted by semantic similarity. When people produced discourse, speech on similar topics elicited similar activation patterns in a widely distributed and bilateral brain network. This network was overlapping with, but more extensive than, the regions that showed similarity effects during comprehension. Critically, cross-task neural similarities between comprehension and production were also predicted by similarities in semantic content. This result suggests that discourse semantics engages a common neural code that is shared between comprehension and production. Effects of semantic similarity were bilateral in all three RSA analyses, even while univariate activation contrasts in the same data indicated left-lateralised BOLD responses. This indicates that right-hemisphere regions encode semantic properties even when they are not activated above baseline. We suggest that right-hemisphere regions play a supporting role in processing the meaning of discourse during both comprehension and production.

neuroscience↗

Power and precision: Evaluation and recommendations of quantitative trait analysis methods for RNA expression levels in the Hybrid Rat Diversity Panel

The Hybrid Rat Diversity Panel (HRDP) is a stable and well-characterized set of more than 90 inbred rat strains that can be leveraged for systems genetics approaches to understanding the genetic and genomic variation associated with complex disease. The HRDP exhibits substantial between-strain diversity while retaining substantial within-strain isogenicity, allowing for the precise mapping of genetic variation associated with complex phenotypes and providing statistical power to identify associated variants. In order to robustly identify associated genetic variants, it is important to account for the population structure induced by inbreeding. To this end, we investigate the performance of various plausible approaches towards modeling quantitative traits in the HRDP and quantify their operating characteristics. Towards facilitating study planning and design, we conduct extensive simulations to investigate the power of genetic association analyses in the HRDP, and characterize the impressive attained power.

systems biology↗

Characterizing the diversity of L2/3 human neocortical neurons in epilepsy

In the current study, we performed whole-cell current clamp recordings from human cortical neurons in layer 2/3 of the human neocortex in order to characterize the diversity of L2/3 human neocortical neurons in epileptic foci with various etiologies in order to begin to elucidate the underlying mechanisms of hyperexcitability which are still mostly unknown. We differentiated neuronal subtypes based on their firing patterns and AHP kinetics or epilepsy subtype (malformation of cortical development (MCD) vs. other (non-MCD)). We found that L2/3 pyramidal neurons have diverse firing properties and action potential kinetics, with some neurons looking remarkably similar to LTS interneurons. We also saw that L2/3 pyramidal neurons could be split into those with fast AHPs and those without, medium AHPs (mAHPs). Based on these parameters, we were unable to significantly differentiate neurons based on firing properties indicating that AHP component kinetics alone do not dictate L2/3 pyramidal neuron firing in human epileptic cortical slices. We also report significant differences in intrinsic properties between MCD and non-MCD and control L2/3 pyramidal neurons and are the first to characterize that wash on of the proconvulsant drug, 4-aminopyridine (4-AP), leads to increased AP duration, less firing rate (FR) accommodation, and slowed down AHPs. Overall, the present study is the first to characterize the large variability of L2/3 human neocortical pyramidal neurons, to compare between L2/3 pyramidal neurons within the epileptic foci between MCD and non-MCD cases, to use control tissue from tumor patients without incidence of seizure, and to determine the influence of 4-AP on L2/3 pyramidal neuron intrinsic properties.

neuroscience↗

Modulation of brain activity by psycholinguistic information during naturalistic speech comprehension and production

Language processing requires the integration of diverse sources of information across multiple levels of processing. A range of psycholinguistic properties have been documented in previous studies as having influence on brain activation during language processing. However, most of those studies have used factorial designs to probe the effect of one or two individual properties using highly controlled stimuli and experimental paradigms. Little is known about the neural correlates of psycholinguistic properties in more naturalistic discourse, especially during language production. The aim of our study is to explore the above issues in a rich fMRI dataset in which participants both listened to recorded passages of discourse and produced their own narrative discourse in response to prompts. Specifically, we measured 13 psycholinguistic properties of the discourse comprehended or produced by the participants, and we used principal components analysis (PCA) to address covariation in these properties and extract a smaller set of latent language characteristics. These latent components indexed vocabulary complexity, sensory-motor and emotional language content, discourse coherence and speech quantity. A parametric approach was adopted to study the effects of these psycholinguistic variables on brain activation during comprehension and production. We found that the pattern of effects across the cortex was somewhat convergent across comprehension and production. However, the degree of convergence varied across language properties, being strongest for the component indexing sensory-motor language content. We report the full, unthresholded effect maps for each psycholinguistic variable, as well as mapping how these effects change along a large-scale cortical gradient of brain function. We believe that our findings provide a valuable starting point for future, confirmatory studies of discourse processing.

neuroscience↗

Dictionary learning for integrative, multimodal, and scalable single-cell analysis

Mapping single-cell sequencing profiles to comprehensive reference datasets represents a powerful alternative to unsupervised analysis. Reference datasets, however, are predominantly constructed from single-cell RNA-seq data, and cannot be used to annotate datasets that do not measure gene expression. Here we introduce bridge integration, a method to harmonize singlecell datasets across modalities by leveraging a multi-omic dataset as a molecular bridge. Each cell in the multi-omic dataset comprises an element in a dictionary, which can be used to reconstruct unimodal datasets and transform them into a shared space. We demonstrate that our procedure can accurately harmonize transcriptomic data with independent single cell measurements of chromatin accessibility, histone modifications, DNA methylation, and protein levels. Moreover, we demonstrate how dictionary learning can be combined with sketching techniques to substantially improve computational scalability, and harmonize 8.6 million human immune cell profiles from sequencing and mass cytometry experiments. Our approach aims to broaden the utility of single-cell reference datasets and facilitate comparisons across diverse molecular modalities. AvailabilityInstallation instructions, documentations, and vignettes are available at http://www.satijalab.org/seurat

genomics↗