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Biology subjects

Herrera, F.

Publications and source records attributed to Herrera, F..

2 recordsLinked to original sources

Automatic whale counting in satellite images with deep learning

Despite their interest and threat status, the number of whales in worlds oceans remains highly uncertain. Whales detection is normally carried out from costly sighting surveys, acoustic surveys or through high-resolution orthoimages. Since deep convolutional neural networks (CNNs) achieve great performance in object-recognition in images, here we propose a robust and generalizable CNN-based system for automatically detecting and counting whales from space based on open data and tools. A test of the system on Google Earth images in ten global whale-watching hotspots achieved a performance (F1-measure) of 84% in detecting and 97% in counting 80 whales. Applying this cost-effective method worldwide could facilitate the assessment of whale populations to guide conservation actions. Free and global access to high-resolution imagery for conservation purposes would boost this process.

ecology

Protein Phosphatase 1 Regulates Huntingtin Exon 1 Aggregation And Toxicity

Huntingtons disease (HD) is neurodegenerative disorder caused by a polyglutamine expansion in the N-terminal region of the huntingtin protein (N17). Here, we analysed the relative contribution of each phosphorylatable residue in the N17 region (T3, S13 and S16) towards huntingtin exon 1 (HTTex1) oligomerization, aggregation and toxicity in human cells and Drosophila neurons. We used bimolecular fluorescence complementation (BiFC) to show that expression of single phosphomimic mutations completely abolished HTTex1 aggregation in human cells. In Drosophila, Mimicking phosphorylation at T3 decreased HTTex1 aggregation both in larvae and adult flies. Interestingly, pharmacological or genetic inhibition of protein phosphatase 1 (PP1) prevented HTTex1 aggregation in both human cells and Drosophila while increasing neurotoxicity in flies. Our findings suggest that PP1 modulates HTTex1 aggregation by regulating phosphorylation on T3. In summary, our study suggests that modulation of HTTex1 single phosphorylation events by PP1 could constitute an efficient and direct molecular target for therapeutic interventions in HD.

neuroscience