Biology subjects

Haque, M. T.

Publications and source records attributed to Haque, M. T..

2 recordsLinked to original sources

bioRxiv2026

Study on The Effect of a Propiconazole Based Fungicide on Plant Growth Promoting Properties of Isolates from Wheat Rhizosphere

Reliance on propiconazole based fungicides has been on the rise for better harvest of crops. Such fungicides can also affect non-target rhizosphere microorganisms. However, the off-target effect of propiconazole on rhizobacteria remains scarcely discussed. The main objective of the present study was to observe the effect of this compound on six plant growth promoting (PGP) properties of wheat rhizosphere isolates using a statistical approach. The study showed that although the overall PGP profile shifted only modestly across propiconazole doses, siderophore and ammonia production were suppressed at the highest fungicide concentration, IAA production declined in the presence of the fungicide, and cellulase activity declined at 4.24 mg/L and above, whereas siderophore appeared to act as a bridge between growth promotion and enzymatic activity. This pattern indicates propiconazole exerts a selective pressure on specific traits rather than holistic disruption. The findings of this study contribute to our understanding of pesticide risk assessment in sustainable agriculture.

microbiology↗

bioRxiv2020

Zika viral proteome analysis reveals an epitope cluster within NS3 helicase as a potential vaccine candidate: an in silico study

Zika virus (ZIKV), a mosquito-borne flavivirus, is now an emerging global public health concern. Currently, the pathogenicity, genetic diversity and the consequences of ZIKV infection are little known but a protective vaccine against ZIKV is an urgency. In this study, we have taken an immunoinformatics based approach to predict epitope cluster region in the whole proteome (3423 amino acids) of ZIKV. We have operated a range of bioinformatics algorithms to determine the epitopes of CD8+ cytotoxic T-cell (CTL), CD4+ helper T-cell (THL) and B cell. We have predicted an epitope cluster of 23 contiguous amino acids (region 1989-2011, WLEARMLLDNIYLQDGLIASLYR) residing on the protein NS3 helicase in ZIKV proteome. This epitope cluster contains fourteen CD4+ (THL) epitopes and six CD8+ (CTL) epitopes. The cluster region predicted to provide 93.86% population coverage worldwide. Finally, we have validated the epitopes by analysing their binding efficiency (binding energy within -4.7 to -6.9 kcal/mol) with specific HLA alleles. Based on our immunoinformatics analysis, we propose the peptide WLEARMLLDNIYLQDGLIASLYR as a new peptide vaccine candidate against Zika virus for further validation.

bioinformatics↗