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Hampson, C. L.

Publications and source records attributed to Hampson, C. L..

2 recordsLinked to original sources

Ethnic Identity Profiles Among Adolescents in the ABCD Study: Associations with Resting State Functional Connectivity and Perceived Discrimination

Ethnic identity refers to how individuals perceive and experience themselves in the context of social groups, racial background, or culture (Phinney & Ong., 2007). Ethnic identity is positively associated with psychological well-being (Rivas-Drake et al., 2014) and negatively associated with depression and anxiety (Forstmeier et al., 2021). Those with strong ethnic identity may display resiliency to the negative effects of discrimination on psychological well-being (Urzua et al., 2021). Phinneys model describes four profiles for how people put effort into, participate in, and reflect upon their ethnic identity (Phinney, 1989). Despite prior work addressing ethnic identity and psychosocial outcomes (for review, see Meca et al., 2023), few studies have considered its neurobiological underpinnings. In the current study, we identified profiles of ethnic identity among participants in The Adolescent Brain Cognitive Development Study (ABCD Study) using latent profile analysis. Next, we examined resting state functional connectivity differences across observed profiles and assessed the moderating effects of perceived discrimination. Results indicated heightened cingulo-parietal (CPAR) network connectivity among adolescents with highly diffuse ethnic identities; among moderately achieved ethnic identities, perceived discrimination moderated the association between ethnic identity and CPAR connectivity. We discuss how these findings may be related to attentional shift, error monitoring, autobiographical memory, and social judgements.

neuroscience↗

Habenula alterations in resting state functional connectivity among autistic individuals

BackgroundThe reward-based theoretical framework of autism suggests that altered reward circuitry contributes to core symptoms. Recent prior research has revealed autism-related structural alterations in the habenula, a small epithalamic structure associated with motivation and emotion; however, potential alterations in functional connectivity (FC) remain unexplored. MethodsAnatomical and resting state functional magnetic resonance imaging (rs-fMRI) data were accessed for 1,479 participants (N=661 autism; agem: 16.68{+/-}8.23 years) in the Autism Brain Imaging Data Exchange (ABIDE). To investigate habenula alterations, we conducted a whole-brain resting state FC analysis using manually delineated subject-specific seeds, followed by regression analyses to explore age and brain-behavior interactions. ResultsAcross the entire sample, extensive habenula connectivity was observed within the midbrain dopaminergic reward system. Compared to neurotypical (NT) controls, autistic participants exhibited significantly increased habenular connectivity with the bilateral middle and superior temporal gyri. From childhood to early adulthood, autistic adolescents displayed an accelerated developmental habenula FC trajectory than NTs with the cingulate gyrus. Between groups, habenula hyperconnectivity was inversely associated with behavioral scores for social motivation and communication. ConclusionsThis study provides novel evidence of habenula connectivity alterations in autism, highlighting atypical FC with sensory processing regions. Further findings suggest that habenula circuitry develops differently among autistic adolescents, with links between habenula hyperconnectivity and social behaviors. Taken together, these results contribute to emerging evidence that the dopaminergic reward system may play a critical role in the pathophysiology of autism.

neuroscience↗