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Halbout, B.

Publications and source records attributed to Halbout, B..

4 recordsLinked to original sources

The Dorsomedial Prefrontal Cortex Uses Reward Predictions to Regulate How Rewards Are Pursued

Reward-predictive cues regulate not only whether but how rewards are pursued, and their influence depends on the strength of their predictive relationship with reward. Whereas weak cues signaling sparse or uncertain reward invigorate instrumental reward seeking, cues signaling imminent reward produce little net invigoration of instrumental behavior and instead promote conditioned goal-approach. We propose that this reflects two opposing influences: an automatic motivational impulse to seek reward, and a top-down, expectancy-dependent control process that constrains it. On this view, the muted or even suppressive effect of imminent-reward cues on instrumental reward seeking reflects an active constraint on motivation rather than its absence. Consistent with this account, we found that selectively devaluing the predicted reward unmasked a latent motivational influence. Cues for imminent reward now invigorated rather than constrained instrumental seeking, suggesting the involvement of a goal-directed regulatory process. Separately, shifting rats from hunger to general satiety abolished the cue-specific regulation of instrumental seeking. We then tested whether the dorsomedial prefrontal cortex (dmPFC) mediates this control. Bulk calcium recordings revealed phasic dmPFC activity that encoded predicted reward probability, dipped when reward was omitted, and covaried with instrumental performance in a cue-dependent manner. Moreover, chemogenetic dmPFC inhibition disrupted the cue-specific regulation of instrumental seeking, leaving rats unable to use these predictions to determine how vigorously to press. These findings identify the dmPFC as a substrate for top-down, expectancy-dependent control over reward pursuit and suggest that its dysfunction may contribute to impulsive or maladaptive reward seeking.

neuroscience↗

Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior

Opioid addiction is a relapsing disorder marked by uncontrolled drug use and reduced interest in normally rewarding activities. The current study investigated the impact of spontaneous withdrawal from chronic morphine exposure on emotional, motivational, and cognitive processes involved in regulating the pursuit and consumption of natural food rewards in male rats. In Experiment 1, rats experiencing acute morphine withdrawal lost weight and displayed somatic signs of drug dependence. However, hedonically-driven sucrose consumption was significantly elevated, suggesting intact and potentially heightened emotional reward processing. In Experiment 2, rats undergoing acute morphine withdrawal displayed reduced motivation when performing an effortful response for palatable food reward. Subsequent reward devaluation testing revealed that acute withdrawal also disrupted their ability to exert flexible goal-directed control over their reward-seeking behavior. Specifically, morphine-withdrawn rats displayed insensitivity to reward devaluation both when relying on prior action-outcome learning and when given direct feedback about the consequences of their actions. In Experiment 3, rats tested after prolonged morphine withdrawal displayed heightened rather than diminished motivation for food rewards and retained their ability to engage in flexible goal-directed action selection. However, brief re-exposure to morphine was sufficient to impair motivation and disrupt goal-directed action selection, though in this case insensitivity to reward devaluation was only observed in the presence of morphine-paired context cues and in the absence of response-contingent feedback. We suggest that these opioid-withdrawal induced deficits in motivation and goal-directed control may contribute to addiction by interfering with the pursuit of adaptive alternatives to drug use.

neuroscience↗

Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats

RationaleThe endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs can cause persistent adaptions in the endocannabinoid system and associated neural circuitry. It remains unclear how such treatments affect the way rewards are processed and pursued. Objective and methodsWe examined if repeated THC exposure (5 mg/kg/day for 14 days) during adolescence or adulthood led to long-term changes in rats capacity to flexibly encode and use action-outcome associations for goal-directed decision making. Effects on hedonic feeding and progressive ratio responding were also assessed. ResultsTHC exposure had no effect on rats ability to flexibly select actions following reward devaluation. However, instrumental contingency degradation learning, which involves avoiding an action that is unnecessary for reward delivery, was augmented in rats with a history of adult but not adolescent THC exposure. THC-exposed rats also displayed more vigorous instrumental behavior in this study, suggesting a motivational enhancement. A separate experiment found that while THC exposure had no effect on hedonic feeding behavior, it increased rats willingness to work for food on a progressive ratio schedule, an effect that was more pronounced when THC was administered to adults. Adolescent and adult THC exposure had opposing effects on the CB1-receptor dependence of progressive ratio performance, decreasing and increasing sensitivity to rimonabant-induced behavioral suppression, respectively. ConclusionsOur findings reveal that exposure to a translationally relevant THC exposure regimen induces long-lasting, age-dependent alterations in cognitive and motivational processes that regulate the pursuit of rewards.

neuroscience↗

Chemogenetic inhibition of ventral tegmental area dopamine neurons or their inputs to the nucleus accumbens disrupts cue-triggered reward seeking but not reward taking

Reward-paired cues stimulate reward-seeking behavior through a combination of motivational and cognitive processes. We used pathway-specific chemogenetic inhibition of dopamine neurons to determine their role in the cue-elicited reward seeking, and applied a novel analytic approach to assay cue-induced changes in reward expectancy. Inhibiting ventral tegmental area dopamine neurons abolished cue-induced reward seeking but not reward retrieval, indicating that this pathway modulates response vigor but not reward expectancy. Locally inhibiting dopamine inputs to nucleus accumbens also disrupted cue-elicited reward seeking but not retrieval. Interestingly, the suppression produced by this treatment was greater in rats that responded to cues with exploratory reward seeking, without attempting to retrieve reward, than in rats exhibiting complete bouts of seeking with retrieval, indicating that individuals differ in their reliance on a dopamine-mediated motivational process. These findings shed new light on the behavioral and neural mechanisms of adaptive and compulsive forms of cue-motivated behavior.

neuroscience↗