Biology subjects

Ghafari, T.

Publications and source records attributed to Ghafari, T..

3 recordsLinked to original sources

bioRxiv2024

STEMorph: Morphed Emotional Face Stimuli

Emotion recognition through facial expressions is crucial for interpreting social cues. However, it is often influenced by biases, i.e., systematic recognition advantages for particular emotions. Nevertheless, these biases are inconsistently reported across studies, likely due to methodological variations which underline the necessity for a standardized approach. Traditional face morphing methods can create unnatural-looking stimuli, and may confound the interpretation of emotions. To address this issue, we here introduce STEMorph, a validated stimulus set based on the NimStim set. We employed neutral-anchored morphing and neural-network-generated masks to reduce morphing artifacts and preserve the coherence of the depicted expressions. We validated our stimulus set by having participants rate each face on a 9-point scale ranging from angry to happy, assessing the perceived emotional intensity. STEMorphs validity was confirmed through linear mixed-effects modelling, showing a strong association between subjective ratings and intended morph level while accounting for other effects. Moreover, aligning with previous research highlighting gender as a key factor in emotion recognition, STEMorph also showed variation across participant-gender dimension. STEMorphs reliability was confirmed through a two-week follow-up rating session with a subgroup of the same participants. By introducing a controlled and empirically evaluated stimulus set of morphed emotional faces, STEMorph provides a useful resource for future investigations of facial emotion recognition.

neuroscience↗

bioRxiv2023

Modulation of alpha oscillations by attention is predicted by hemispheric asymmetries of subcortical regions.

Evidence suggests that subcortical structures play a role in high-level cognitive functions such as the allocation of spatial attention. While there is abundant evidence in humans for posterior alpha band oscillations being modulated by spatial attention, little is known about how subcortical regions contribute to these oscillatory modulations, particularly under varying conditions of cognitive challenge. In this study, we combined MEG and structural MRI data to investigate the role of subcortical structures in controlling the allocation of attentional resources by employing a cued spatial attention paradigm with varying levels of perceptual load. We asked whether hemispheric lateralization of volumetric measures of the thalamus and basal ganglia predicted the hemispheric modulation of alpha-band power. Lateral asymmetry of the globus pallidus, caudate nucleus, and thalamus predicted attention-related modulations of posterior alpha oscillations. When the perceptual load was applied to the target and the distractor was salient caudate nucleus asymmetry predicted alpha-band modulations. Globus Pallidus was predictive of alpha-band modulations when either the target had a high load, or the distractor was salient, but not both. Finally, the asymmetry of the thalamus predicted alpha band modulation when neither component of the task was perceptually demanding. In addition to delivering new insight into the subcortical circuity controlling alpha oscillations with spatial attention, our finding might also have clinical applications. We provide a framework that could be followed for detecting how structural changes in subcortical regions that are associated with neurological disorders can be reflected in the modulation of oscillatory brain activity.

neuroscience↗

bioRxiv2023

An adversarial collaboration to critically evaluate theories of consciousness

Different theories explain how subjective experience arises from brain activity1,2. These theories have independently accrued evidence, yet, confirmation bias and dependence on design choices hamper progress in the field3. Here, we present an open science adversarial collaboration which directly juxtaposes Integrated Information Theory (IIT)4,5 and Global Neuronal Workspace Theory (GNWT)6-10, employing a theory-neutral consortium approach11,12. We investigate neural correlates of the content and duration of visual experience. The theory proponents and the consortium developed and preregistered the experimental design, divergent predictions, expected outcomes, and their interpretation12. 256 human subjects viewed suprathreshold stimuli for variable durations while neural activity was measured with functional magnetic resonance imaging, magnetoencephalography, and electrocorticography. We find information about conscious content in visual, ventro-temporal and inferior frontal cortex, with sustained responses in occipital and lateral temporal cortex reflecting stimulus duration, and content-specific synchronization between frontal and early visual areas. These results confirm some predictions of IIT and GNWT, while substantially challenging both theories: for IIT, a lack of sustained synchronization within posterior cortex contradicts the claim that network connectivity specifies consciousness. GNWT is challenged by the general lack of ignition at stimulus offset and limited representation of certain conscious dimensions in prefrontal cortex. Beyond challenging the theories themselves, we present an alternative approach to advance cognitive neuroscience through a principled, theory-driven, collaborative effort. We highlight the challenges to change peoples mind 13 and the need for a quantitative framework integrating evidence for systematic theory testing and building.

neuroscience↗