Biology subjects

Gestin, M.

Publications and source records attributed to Gestin, M..

2 recordsLinked to original sources

bioRxiv2025

AI4CellFate: Interpretable Early Cell Fate Prediction with Generative AI

Live-cell imaging provides a unique insight into complex cellular processes including single cell fate, but remains limited by both low-throughput and the lack of generalisable analytics for the multidimensional datasets it produces. This work introduces AI4CellFate, an interpretable and data-driven machine learning framework for predicting cell fate from microscopy timelapses, applied here to cancer therapy. By integrating generative AI and contrastive learning, AI4CellFate enables early fate prediction as well as visualisation of biologically relevant features, with limited annotation.

bioinformatics↗

bioRxiv2020

Mimicry of dopamine 1 receptor signaling with Cell-Penetrating Peptides

In this study, through the use of protein mimicry, a peptide was developed to activate the dopamine 1 receptor signaling pathway in substitution of L-DOPA. The peptide proved to be capable of efficiently ubiquitously penetrating the cell without the need for transfection agents or chiral recognition by specific pathways. Furthermore, the peptide induced the cellular response normally achieved through the activation of the receptor in cells that had not been treated with the natural ligand. The peptide could work as a candidate substitute to L-DOPA, leading the way for a peptides-based treatment for Parkinsons disease.

pharmacology and toxicology↗