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Biology subjects

Feuerriegel, S.

Publications and source records attributed to Feuerriegel, S..

2 recordsLinked to original sources

Uneven research attention to biodiversity loss revealed by large language models

Biological diversity is crucial for ecosystem functioning and human well-being but is declining under multiple pressures from human activity. Research on biodiversity loss spans multiple ecological contexts, yet existing syntheses typically cover only subsets of the evidence base. We developed a systematic mapping framework based on large language models to screen and synthesize the scientific literature on biodiversity loss at scale. Applying our framework to 2.4 million bibliographic records, we identified 253,081 scientific articles on biodiversity loss, which we classified across five dimensions: geography, ecosystems, taxa, direct drivers (e.g., land- and sea-use change, climate change, and pollution), and specific threats (e.g., agriculture, hunting, and urban development). Chordates accounted for 34.8% of research attention but only 4.6% of described species. We find comparatively limited research attention to non-chordate animals, studies in Africa, and direct exploitation in marine systems. Overall, our systematic map provides a multidimensional view of research attention to biodiversity loss across various ecological contexts and can help identify evidence gaps to inform future research priorities.

ecology↗

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia

Bacterial factors favoring the unprecedented multidrug-resistant tuberculosis (MDR-TB) epidemic in the former Soviet Union remain unclear.\n\nWe utilized whole genome sequencing and Bayesian statistics to analyze the evolutionary history, temporal emergence of resistance and transmission networks of MDR-MTBC strains from Karakalpakstan, Uzbekistan (2001-2006).\n\nOne MTBC-clone (termed Central Asian outbreak, CAO) with resistance mediating mutations to eight anti-TB drugs existed prior the worldwide introduction of standardized WHO-endorsed directly observed treatment, short-course (DOTS). DOTS implementation in Karakalpakstan in 1998 likely selected for these CAO-strains, comprising 75% of sampled MDR-TB strains in 2005/2006. CAO-strains were also identified in a previously published cohort from Samara, Russia (2008-2010). Similarly, transmission success and resistance development was linked to mutations compensating fitness deficits associated with rifampicin resistance.\n\nThe genetic make-up of these outbreak clades threatens the success of both empirical and standardized guideline driven MDR-TB therapies, including the newly WHO-endorsed short MDR-TB regimen in Uzbekistan.

evolutionary biology↗