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Farahibozorg, S.-R.

Publications and source records attributed to Farahibozorg, S.-R..

13 recordsLinked to original sources

Bi-cross-validation: a data-driven method to evaluate dynamic functional connectivity models in fMRI

Dynamic functional connectivity (dFC) models have become increasingly popular over the past decade for characterising time-varying interactions between brain regions. However, assessing and comparing dFC models remains challenging. Here, we introduce bi-cross-validation as a general framework for evaluating dFC models and selecting key hyperparameters, such as the number of states. By jointly partitioning the data across subjects and brain regions, bi-cross-validation enables out-of-sample evaluation without re-estimating latent states on the same data used for testing, thereby avoiding circularity. Using simulated data with known ground-truth dynamics, we show that bi-cross-validation favours models that accurately capture the underlying state structure. Applying the framework to real resting-state fMRI data, we demonstrate that bi-cross-validation naturally balances goodness-of-fit against model complexity, with performance improving and then declining as model complexity increases. Finally, we use bi-cross-validation to directly compare static and dynamic FC models, showing that dynamic models underperform static models at low spatial dimensionality, but outperform static models at sufficiently high dimensionality. Together, these results establish bi-cross-validation as a principled tool for dFC model selection, evaluation, and comparison.

neuroscience↗

Automatic Individual Cortical Parcellation for the Human Connectome Project

The original Human Connectome Project multimodal cortical parcellation (HCP_MMP1.0) used MRI-derived local features and long-distance functional connectivity measures to define a multimodal parcellation at the group level, accompanied by an automated areal classifier, to create subject-specific mappings of the human cerebral cortex. These mappings, referred to as individual (cortex) parcellations, aim to capture individual variability in areal organization by learning from both structural and functional data. However, a strict supervised learning approach using the group parcellation as labels would have no incentive to learn individual differences that registration is unable to reconcile (e.g., atypical 55b topologies). Furthermore, there are many types of resting state network (RSN) feature maps, and it is unclear which type would most accurately or effectively classify areas, or even what should be the primary criteria for evaluating classification performance. Here, we introduce an Areal Recognition Ensemble with Nested Approach (ARENA) classifier that learns from uncertain labels, using a novel application of weakly supervised learning to this type of problem. Additionally, in comparing multiple candidate RSN decompositions, temporal ICA and PROFUMO maps outperformed the original spatial ICA-based approach based on objective criteria. With these refinements, the ensemble classifier achieved a reliable individual variability score of 8380, an average areal detection rate of 97.8%, and test-retest reproducibility of 73.3%, outperforming a retrained version of the original Multi-layer Perceptron (MLP) model (whose reliable individual variability score was 3128, average areal detection rate was 97.2%, and test-retest reproducibility was 71.6% on the same dataset). Furthermore, the ARENA classifier demonstrated stronger generalization for all three measures when applied to task fMRI data that were not part of the training dataset. Using the refined classifier and leveraging all 1071 HCP-Young Adult subjects, we identified new types of atypical organization of language-related area 55b. Here we provide the fully data-driven HCP_MMP1.0_1071_MPM (Maximum Probability Map) group parcellation and a summary of area 55b organization in both hemispheres. Our automated individual parcellation pipeline powered by the novel ARENA classifier is now integrated into the HCP pipelines, offering a user-friendly tool for the neuroimaging community.

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The developing Human Connectome Project fetal functional MRI release: Methods and data structures

Recent advances in fetal fMRI present a new opportunity for neuroscience to study functional human brain connectivity at the time of its emergence. Progress in the field however has been hampered by the lack of openly available datasets that can be exploited by researchers across disciplines to develop methods that would address the unique challenges associated with imaging and analysing functional brain in utero, such as unconstrained head motion, dynamically evolving geometric distortions, or inherently low signal-to-noise ratio. Here we describe the developing Human Connectome Projects release of the largest open access fetal fMRI dataset to date, containing 275 scans from 255 fetuses and spanning the period of 20.86 to 38.29 post-menstrual weeks. We present a systematic approach to its pre-processing, implementing multi-band soft SENSE reconstruction, dynamic distortion corrections via phase unwrapping method, slice-to-volume reconstruction and a tailored temporal filtering model, with attention to the prominent sources of structured noise in the in utero fMRI. The dataset is accompanied with an advanced registration infrastructure, enabling group-level data fusion, and contains outputs from the main intermediate processing steps. This allows for various levels of data exploration by the imaging and neuroscientific community, starting from the development of robust pipelines for anatomical and temporal corrections to methods for elucidating the development of functional connectivity in utero. By providing a high-quality template for further method development and benchmarking, the release of the dataset will help to advance fetal fMRI to its deserved and timely place at the forefront of the efforts to build a life-long connectome of the human brain.

neuroscience↗

Evaluating functional brain organization in individuals and identifying contributions to network overlap

Individual differences in the spatial organization of resting state networks have received increased attention in recent years. Measures of individual-specific spatial organization of brain networks and overlapping network organization have been linked to important behavioral and clinical traits and are therefore potential biomarker targets for personalized psychiatry approaches. To better understand individual-specific spatial brain organization, this paper addressed three key goals. First, we determined whether it is possible to reliably estimate weighted (non-binarized) resting state network maps using data from only a single individual, while also maintaining maximum spatial correspondence across individuals. Second, we determined the degree of spatial overlap between distinct networks, using test-retest and twin data. Third, we systematically tested multiple hypotheses (spatial mixing, temporal switching, and coupling) as candidate explanations for why networks overlap spatially. To estimate weighted network organization, we adopt the Probabilistic Functional Modes (PROFUMO) algorithm, which implements a Bayesian framework with hemodynamic and connectivity priors to supplement optimization for spatial sparsity/independence. Our findings showed that replicable individual-specific estimates of weighted resting state networks can be derived using high quality fMRI data within individual subjects. Network organization estimates using only data from each individual subject closely resembled group-informed network estimates (which was not explicitly modeled in our individual-specific analyses), suggesting that cross-subject correspondence was largely maintained. Furthermore, our results confirmed the presence of spatial overlap in network organization, which was replicable across sessions within individuals and in monozygotic twin pairs. Intriguingly, our findings provide evidence that network overlap is indicative of linear additive coupling. These results suggest that regions of network overlap concurrently process information from all contributing networks, potentially pointing to the role of overlapping network organization in the integration of information across multiple brain systems.

neuroscience↗

Comparison Between Gradients and Parcellations for Functional Connectivity Prediction of Behavior

Resting-state functional connectivity (RSFC) is widely used to predict behavioral measures. To predict behavioral measures, representing RSFC with parcellations and gradients are the two most popular approaches. Here, we compare parcellation and gradient approaches for RSFC-based prediction of a broad range of behavioral measures in the Human Connectome Project (HCP) and Adolescent Brain Cognitive Development (ABCD) datasets. Among the parcellation approaches, we consider group-average "hard" parcellations (Schaefer et al., 2018), individual-specific "hard" parcellations (Kong et al., 2021a), and an individual-specific "soft" parcellation (spatial independent component analysis with dual regression; Beckmann et al., 2009). For gradient approaches, we consider the well-known principal gradients (Margulies et al., 2016) and the local gradient approach that detects local RSFC changes (Laumann et al., 2015). Across two regression algorithms, individual-specific hard-parcellation performs the best in the HCP dataset, while the principal gradients, spatial independent component analysis and group-average "hard" parcellations exhibit similar performance. On the other hand, principal gradients and all parcellation approaches perform similarly in the ABCD dataset. Across both datasets, local gradients perform the worst. Finally, we find that the principal gradient approach requires at least 40 to 60 gradients to perform as well as parcellation approaches. While most principal gradient studies utilize a single gradient, our results suggest that incorporating higher order gradients can provide significant behaviorally relevant information. Future work will consider the inclusion of additional parcellation and gradient approaches for comparison.

neuroscience↗

Maturational networks of fetal brain activity

A key feature of the fetal period is the rapid emergence of organised patterns of spontaneous brain activity. However, characterising this process in utero using functional MRI is inherently challenging and requires analytical methods which can capture the constituent developmental transformations. Here, we introduce a novel analytical framework, termed "maturational networks" (matnets), that achieves this by modelling functional networks as an emerging property of the developing brain. Compared to standard network analysis methods that assume consistent patterns of connectivity across development, our method incorporates age-related changes in connectivity directly into network estimation. We test its performance in a large neonatal sample, finding that the matnets approach characterises adult-like features of functional network architecture with a greater specificity than a standard group-ICA approach; for example, our approach is able to identify a nearly complete default mode network. In the in-utero brain, matnets enables us to reveal the richness of emerging functional connections and the hierarchy of their maturational relationships with remarkable anatomical specificity. We show that the associative areas play a central role within prenatal functional architecture, therefore indicating that functional connections of high-level associative areas start emerging prior to exposure to the extra-utero environment.

neuroscience↗

Time Lagged Multidimensional Pattern Connectivity (TL MDPC): An EEG/MEG Pattern Transformation Based Functional Connectivity Metric

Functional and effective connectivity methods are essential to study the complex information flow in brain networks underlying human cognition. Only recently have connectivity methods begun to emerge that make use of the full multidimensional information contained in patterns of brain activation, rather than univariate summary measures of these patterns. To date, these methods have mostly been applied to fMRI data, and no method allows vertex-vertex transformation with the temporal specificity of EEG/MEG data. Here, we introduce time-lagged multidimensional pattern connectivity (TL-MDPC) as a novel bivariate functional connectivity metric for EEG/MEG research. TL-MDPC estimates the vertex-to-vertex transformations among multiple brain regions and across different latency ranges. It determines how well patterns in ROI X at time point tx can linearly predict patterns of ROI Y at time point ty. In the present study, we use simulations to demonstrate TL-MDPCs increased sensitivity to multidimensional effects compared to a univariate approach across realistic choices of number of trials and signal-to-noise ratio. We applied TL-MDPC, as well as its univariate counterpart, to an existing dataset varying the depth of semantic processing of visually presented words by contrasting a semantic decision and a lexical decision task. TL-MDPC detected significant effects beginning very early on, and showed stronger task modulations than the univariate approach, suggesting that it is capable of capturing more information. With TL-MDPC only, we observed rich connectivity between core semantic representation (left and right anterior temporal lobes) and semantic control (inferior frontal gyrus and posterior temporal cortex) areas with greater semantic demands. TL-MDPC is a promising approach to identify multidimensional connectivity patterns, typically missed by univariate approaches. HighlightsO_LITL-MDPC is a multidimensional functional connectivity method for event-related EMEG C_LIO_LITL-MDPC captures both univariate and multidimensional connectivity C_LIO_LITL-MDPC yields both zero-lag and time-lagged dependencies C_LIO_LITL-MDPC produced richer connectivity than univariate approaches in a semantic task C_LIO_LITL-MDPC identified connectivity between the ATL hubs and semantic control regions C_LI

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Accurate predictions of individual differences in task-evoked brain activity from resting-state fMRI using a sparse ensemble learner

Modelling and predicting individual differences in task-evoked FMRI activity can have a wide range of applications from basic to clinical neuroscience. It has been shown that models based on resting-state activity can have high predictive accuracy. Here we propose several improvements to such models. Using a sparse ensemble leaner, we show that (i) features extracted using Stochastic Probabilistic Functional Modes (sPROFUMO) outperform the previously proposed dual-regression approach, (ii) that the shape and overall intensity of individualised task activations can be modelled separately and explicitly, (iii) training the model on predicting residual differences in brain activity further boosts individualised predictions. These results hold for both surface-based analyses of the Human Connectome Project data as well as volumetric analyses of UK-biobank data. Overall, our model achieves state of the art prediction accuracy on par with the test-retest reliability of tfMRI scans, suggesting that it has potential to supplement traditional task localisers.

neuroscience↗

Task modulation of spatiotemporal dynamics in semantic brain networks: an EEG/MEG study

How does brain activity in distributed semantic brain networks evolve over time, and how do these regions interact to retrieve the meaning of words? We compared spatiotemporal brain dynamics between visual lexical and semantic decision tasks (LD and SD), analysing whole-cortex evoked responses and spectral functional connectivity (coherence) in source-estimated electroencephalography and magnetoencephalography (EEG and MEG) recordings. Our evoked analysis revealed generally larger activation for SD compared to LD, starting in primary visual area (PVA) and angular gyrus (AG), followed by left posterior temporal cortex (PTC) and left anterior temporal lobe (ATL). The earliest activation effects in ATL were significantly left-lateralised. Our functional connectivity results showed significant connectivity between left and right ATLs and PTC and right ATL in an early time window, as well as between left ATL and IFG in a later time window. The connectivity of AG was comparatively sparse. We quantified the limited spatial resolution of our source estimates via a leakage index for careful interpretation of our results. Our findings suggest that semantic task demands modulate visual and attentional processes early-on, followed by modulation of multimodal semantic information retrieval in ATLs and then control regions (PTC and IFG) in order to extract task-relevant semantic features for response selection. Whilst our evoked analysis suggests a dominance of left ATL for semantic processing, our functional connectivity analysis also revealed significant involvement of right ATL in the more demanding semantic task. Our findings demonstrate the complementarity of evoked and functional connectivity analysis, as well as the importance of dynamic information for both types of analyses. HighlightsO_LISemantic task demands affect activity and connectivity at different processing stages C_LIO_LIEarliest task modulations occurred in posterior visual brain regions C_LIO_LIATL, PTC and IFG effects reflect task-relevant retrieval of multimodal information C_LIO_LIATL effects left-lateralised for activation but bilateral for functional connectivity C_LIO_LIDynamic evoked and connectivity data are essential to study semantic networks C_LI

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Hierarchical modelling of functional brain networks in population and individuals from big fMRI data

A major goal of large-scale brain imaging datasets is to provide resources for investigating heterogeneous populations. Characterisation of functional brain networks for individual subjects from these datasets will have an enormous potential for prediction of cognitive or clinical traits. We propose for the first time a technique, Stochastic Probabilistic Functional Modes (sPROFUMO), that is scalable to UK Biobank (UKB) with expected 100,000 participants, and hierarchically estimates functional brain networks in individuals and the population, while allowing for bidirectional flow of information between the two. Using simulations, we show the models utility, especially in scenarios that involve significant cross-subject variability, or require delineation of fine-grained differences between the networks. Subsequently, by applying the model to resting-state fMRI from 4999 UKB subjects, we mapped resting state networks (RSNs) in single subjects with greater detail than has been possible previously in UKB (>100 RSNs), and demonstrate that these RSNs can predict a range of sensorimotor and higher-level cognitive functions. Furthermore, we demonstrate several advantages of the model over independent component analysis combined with dual-regression (ICA-DR), particularly with respect to the estimation of the spatial configuration of the RSNs and the predictive power for cognitive traits. The proposed model and results can open a new door for future investigations into individualised profiles of brain function from big data. HighlightsO_LIWe introduce stochastic PROFUMO (sPROFUMO) for inferring functional brain networks from big data C_LIO_LIsPROFUMO hierarchically estimates fMRI networks for the population and every individual C_LIO_LIWe characterised high dimensional resting state fMRI networks from UK Biobank C_LIO_LIModel outperforms ICA and dual regression for estimation of individual-specific network topography C_LIO_LIWe demonstrate the models utility for predicting cognitive traits, and capturing subject variability in network topographies versus connectivity C_LI

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The developing Human Connectome Project (dHCP) automated resting-state functional processing framework for newborn infants.

The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20 to 45 weeks post-menstrual age. This is being achieved through the acquisition of multi-modal MRI data from over 1000 in- and ex-utero subjects combined with the development of optimised pre-processing pipelines. In this paper we present an automated and robust pipeline to minimally pre-process highly confounded neonatal resting-state fMRI data, robustly, with low failure rates and high quality-assurance. The pipeline has been designed to specifically address the challenges that neonatal data presents including low and variable contrast and high levels of head motion. We provide a detailed description and evaluation of the pipeline which includes integrated slice-to-volume motion correction and dynamic susceptibility distortion correction, a robust multimodal registration approach, bespoke ICA-based denoising, and an automated QC framework. We assess these components on a large cohort of dHCP subjects and demonstrate that processing refinements integrated into the pipeline provide substantial reduction in movement related distortions, resulting in significant improvements in SNR, and detection of high quality RSNs from neonates. HighlightsO_LIAn automated and robust pipeline to minimally pre-process highly confounded neonatal fMRI data C_LIO_LIIncludes integrated dynamic distortion and slice-to-volume motion correction C_LIO_LIA robust multimodal registration approach which includes custom neonatal templates C_LIO_LIIncorporates an automated and self-reporting QC framework to quantify data quality and identify issues for further inspection C_LIO_LIData analysis of 538 infants imaged at 26-45 weeks post-menstrual age C_LI

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Distinct roles for the Anterior Temporal Lobe and Angular Gyrus in the spatio-temporal cortical semantic network

It is now well recognised that human semantic knowledge is supported by a large neural network distributed over multiple brain regions, but the dynamic organisation of this network remains unknown. Some studies have proposed that a central semantic hub coordinates this network. We explored the possibility of different types of semantic hubs; namely "representational hubs", whose neural activity is modulated by semantic variables, and "connectivity hubs", whose connectivity to distributed areas is modulated by semantic variables. We utilised the spatio-temporal resolution of source-estimated Electro-/Magnetoencephalography data in a word-concreteness task (17 participants, 12 female) in order to: (i) find representational hubs at different timepoints based on semantic modulation of evoked brain activity in source space; (ii) identify connectivity hubs among left Anterior Temporal Lobe (ATL), Angular Gyrus (AG), Middle Temporal Gyrus and Inferior Frontal Gyrus based on their functional connectivity to the whole cortex, in particular sensory-motor-limbic systems; and (iii) explicitly compare network models with and without an intermediate hub linking sensory input to other candidate hub regions using Dynamic Causal Modelling (DCM) of evoked responses. ATLs activity was modulated as early as 150ms post-stimulus, while both ATL and AG showed modulations of functional connectivity with sensory-motor-limbic areas from 150-450ms. DCM favoured models with one intermediate hub, namely ATL in an early time window and AG in a later time-window. Our results support ATL as a single representational hub with an early onset, but suggest that both ATL and AG function as connectivity hubs depending on the stage of semantic processing.

neuroscience↗

Adaptive Cortical Parcellations for Source Reconstructed EEG/MEG Connectomes

There is growing interest in the rich temporal and spectral properties of the brain's functional connectome that are provided by Electro- and Magnetoencephalography (EEG/MEG). However, the problem of leakage between brain sources that arises when reconstructing brain activity from EEG/MEG recordings outside the head makes it difficult to distinguish true connections from spurious connections, even when connections are based on measures that ignore zero-lag dependencies. In particular, standard anatomical parcellations for potential cortical sources tend to over- or under-sample the real spatial resolution of EEG/MEG. By using information from cross-talk functions (CTFs) that objectively describe leakage for a given sensor configuration and distributed source reconstruction method, we introduce methods for optimising the number of parcels while simultaneously minimising the leakage between them. More specifically, we compare two image segmentation algorithms: 1) a split-and-merge (SaM) algorithm based on standard anatomical parcellations and 2) a region growing (RG) algorithm based on all the brain vertices with no prior parcellation. Interestingly, when applied to minimum-norm reconstructions for EEG/MEG configurations from real data, both algorithms yielded approximately 70 parcels despite their different starting points, suggesting that this reflects the resolution limit of this particular sensor configuration and reconstruction method. Importantly, when compared against standard anatomical parcellations, resolution matrices of adaptive parcellations showed notably higher sensitivity and distinguishability of parcels. Furthermore, extensive simulations of realistic networks under various circumstances revealed significant improvements in network reconstruction accuracies, particularly in reducing false leakage-induced connections. Adaptive parcellations therefore allow a more accurate reconstruction of functional EEG/MEG connectomes.\n\nHighlightsO_LIWe introduce adaptive cortical parcellation algorithms for E/MEG source estimation.\nC_LIO_LIAlgorithms are based on cross-talk functions and image segmentation methods.\nC_LIO_LIThe resulting parcellations yielded ~70 parcels regardless of starting point.\nC_LIO_LISensitivity and distinguishability improved compared to anatomical parcellations.\nC_LIO_LIAccuracy of realistic whole-brain network reconstruction improved significantly.\nC_LI

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