Search bioRxiv⌕ Search

Biology subjects

Escolano, C.

Publications and source records attributed to Escolano, C..

2 recordsLinked to original sources

Garments that measure EEG: Evaluation of an EEG sensor layer fully implemented with smart textiles

This paper presents the first garment capable of measuring EEG activity with accuracy comparable to state-of-the art dry EEG systems. The main innovation is an EEG sensor layer (i.e., the electrodes, the signal transmission, and the cap support) fully implemented as a garment, using threads, fabrics and smart textiles, without relying on any metal or plastic materials. The garment is interfaced via a connector to a mobile EEG amplifier to complete the measurement system. The new EEG system (Garment-EEG) has been characterized with respect to a state-of-the-art Ag/AgCl dry-EEG system (Dry-EEG) over the forehead area of healthy participants in terms of: (1) skin-electrode impedance; (2) electrophysiological measurements (spontaneous and evoked EEG activity); (3) artifacts; and (4) user ergonomics and comfort. The results show that the Garment-EEG system provides comparable recordings to Dry-EEG, but it is more prone to getting affected by artifacts in adverse recording conditions due to poorer contact impedances. Ergonomics and comfort favor the textile-based sensor layer with respect to its metal-based counterpart. User acceptance is the main obstacle for EEG systems to democratize neurotechnology and non-invasive brain-computer interfaces. EEG sensor layers encapsulated in wearables have the potential to enable neurotechnology that is naturally accepted by people in their daily lives. Furthermore, by supporting the EEG implementation in the textile industry it is manufactured with lower cost and much less pollution compared to the metal and plastic industries.

neuroscience↗

Pharmacological inhibition of soluble epoxide hydrolase as a new therapy for Alzheimer’s Disease

The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical therapeutic effects in several peripheral inflammatory-related diseases, with two compounds that have entered clinical trials. However, the role of this enzyme in the neuroinflammation process has been largely neglected. Herein, we disclose the pharmacological validation of sEH as a novel target for the treatment of Alzheimers Disease (AD). Of interest, we have found that sEH is upregulated in brains from AD patients. We have evaluated the cognitive impairment and the pathological hallmarks in two models of age-related cognitive decline and AD using three structurally different and potent sEH inhibitors as chemical probes. Our findings supported our expectations on the beneficial effects of central sEH inhibition, regarding of reducing cognitive impairment, tau hyperphosphorylation pathology and the number of amyloid plaques. Interestingly, our results suggest that reduction of inflammation in the brain is a relevant therapeutic strategy for all stages of AD.

pharmacology and toxicology↗