Search bioRxiv⌕ Search

Biology subjects

Doan, E.

Publications and source records attributed to Doan, E..

2 recordsLinked to original sources

Techniques and challenges in studying photosynthetic diversity in freshwater aquatic vascular plants

While the photosynthetic diversity of aquatic plants rivals that of terrestrial species, the environmental conditions underlying that diversity fundamentally differ. Despite these environmental differences, aquatic and terrestrial plants have convergently evolved Carbon Concentrating Mechanisms (CCMs). However, characterization of these pathways in submerged plants has lagged behind terrestrial systems due to methodological constraints of the aquatic environment. Here we review and evaluate contemporary methods for detecting CCMs in aquatic plants. Physiological methods including gas exchange and isotopic analyses provide valuable insights in terrestrial plants but face significant challenges in aquatic systems. Biochemical assays of organic acid accumulation reliably detect CCMs in aquatic species but may struggle to detect weak or non-canonical CCMs in submerged plants. Finally, we propose a method for targeted molecular assays of phosphoenolpyruvate carboxylase (PEPC) expression that could provide a sensitive tool for characterizing photosynthetic diversity in a wide range of aquatic species. Our results show that methods and frameworks developed for terrestrial plants do not necessarily directly translate to aquatic systems. However, by extending these methods and integrating multiple lines of evidence we can improve our ability to characterize photosynthetic diversity in aquatic plants.

plant biology↗

Combinatorial CRISPR screens and lectin microarrays identify novel glycosylation regulators

Glycans play critical roles in cellular signaling and function. Unlike proteins, glycan structures are not templated from genes but the concerted activity of many genes, making them historically challenging to study. Here, we present a strategy that utilizes pooled CRISPR screens and lectin microarrays to uncover and characterize regulators of cell surface glycosylation. We applied this approach to study the regulation of high mannose glycans - the starting structure of all asparagine(N)-linked-glycans. We used CRISPR screens to uncover the expanded network of genes controlling high mannose surface levels, followed by lectin microarrays to fully measure the complex effect of select regulators on glycosylation globally. Through this, we elucidated how two novel high mannose regulators - TM9SF3 and the CCC complex - control complex N-glycosylation via regulating Golgi morphology and function. Notably, this method allowed us to interrogate Golgi function in-depth and reveal that similar disruption to Golgi morphology can lead to drastically different glycosylation outcomes. Collectively, this work demonstrates a generalizable approach for systematically dissecting the regulatory network underlying glycosylation.

cell biology↗