Biology subjects

Diveica, V.

Publications and source records attributed to Diveica, V..

5 recordsLinked to original sources

bioRxiv2026

Social Experience and Motivated Cognition Shape the Representation of Concepts: A Behavioural and Functional Neuroimaging Study

The ventrolateral anterior temporal lobe (vlATL), including the anterior inferior temporal and fusiform gyri, is the centre of a supramodal and category-general hub for semantic representation. Dorsolateral ATL regions, such as the temporal pole (TP) and anterior middle temporal gyrus (aMTG), have been associated with more specialised semantic function, including social concept processing, although the precise location and laterality of these effects vary across studies, prohibiting firm conclusions. The socialness of concepts has been defined in numerous different ways which, along with uncontrolled effects of other semantic dimensions, could explain inconsistencies in previous behavioural and neuroimaging findings. Therefore, we used a new set of validated socialness norms to compare social and non-social concept processing, while controlling for other important semantic variables, including concreteness and valence. Moreover, we report the first investigation of a potential link between socialness and motivation. This was aimed at unpacking the informational content or processes that make social concepts unique, and particularly a putative role of reward processing. We report two pre-registered experiments, one behavioural (N = 89) and one using fMRI (N = 30), examining the orthogonal effects of socialness and motivation on semantic decisions. Consistent with other recent findings, social concepts were processed more accurately than non-social concepts. Left TP activation was driven by social concepts but not non-social concepts, and some evidence suggests there is also right TP selectivity for social concepts. All concept types engaged the left vlATL and bilateral aMTG suggestive of a category-general semantic function. Multivariate pattern analyses found distinguishable local activation patterns associated with social vs non-social concepts in the left TP, aMTG, and vlATL, and for high vs low motivation concepts in the left TP and aMTG. The activation patterns encoding socialness in the aMTG generalized across levels of motivation, suggesting that socialness is encoded independently of motivation-related information. These findings align with multiple representation theories that claim social and reward-related experiences contribute to semantic representation. They also particularly pinpoint the left TP as having a preference for social concepts.

neuroscience↗

bioRxiv2023

Overlapping Neural Correlates Underpin Theory of Mind and Semantic Cognition: Evidence from a Meta-Analysis of 344 Functional Neuroimaging Studies

Key unanswered questions for cognitive neuroscience include whether social cognition is underpinned by specialised brain regions and to what extent it simultaneously depends on more domain-general systems. Until we glean a better understanding of the full set of contributions made by various systems, theories of social cognition will remain fundamentally limited. In the present study, we evaluate a recent proposal that semantic cognition plays a crucial role in supporting social cognition. While previous brain-based investigations have focused on dissociating these two systems, our primary aim was to assess the degree to which the neural correlates are overlapping, particularly within two key regions, the anterior temporal lobe (ATL) and the temporoparietal junction (TPJ). We focus on activation associated with theory of mind (ToM) and adopt a meta-analytic activation likelihood approach to synthesise a large set of functional neuroimaging studies and compare their results with studies of semantic cognition. As a key consideration, we sought to account for methodological differences across the two sets of studies, including the fact that ToM studies tend to use nonverbal stimuli while the semantics literature is dominated by language-based tasks. Overall, we observed consistent overlap between the two sets of brain regions, especially in the ATL and TPJ. This supports the claim that tasks involving ToM draw upon more general semantic retrieval processes. We also identified activation specific to ToM in the right TPJ, bilateral anterior mPFC, and right precuneus. This is consistent with the view that, nested amongst more domain-general systems, there is specialised circuitry that is tuned to social processes.

neuroscience↗

bioRxiv2023

Graded functional organisation in the left inferior frontal gyrus: evidence from task-free and task-based functional connectivity

The left inferior frontal gyrus (LIFG) has been ascribed key roles in numerous cognitive domains, including language, executive function and social cognition. However, its functional organisation, and how the specific areas implicated in these cognitive domains relate to each other, is unclear. Possibilities include that the LIFG underpins a domain-general function or, alternatively, that it is characterized by functional differentiation, which might occur in either a discrete or a graded pattern. The aim of the present study was to explore the topographical organisation of the LIFG using a bimodal data-driven approach. To this end, we extracted functional connectivity (FC) gradients from 1) the resting-state fMRI time-series of 150 participants (77 female), and 2) patterns of co-activation derived meta-analytically from task data across a diverse set of cognitive domains. We then sought to characterize the FC differences driving these gradients with seed-based resting-state FC and meta-analytic co-activation modelling analyses. Both analytic approaches converged on an FC profile that shifted in a graded fashion along two main organisational axes. An anterior-posterior gradient shifted from being preferentially associated with high-level control networks (anterior LIFG) to being more tightly coupled with perceptually-driven networks (posterior). A second dorsal-ventral axis was characterized by higher connectivity with domain-general control networks on one hand (dorsal LIFG), and with the semantic network, on the other (ventral). These results provide novel insights into a graded functional organisation of the LIFG underpinning both task-free and task-constrained mental states, and suggest that the LIFG is an interface between distinct large-scale functional networks. Significance statementTo understand how function varies across the LIFG, we conducted a detailed, bimodal exploration of the spatial transitions in its voxel-wise FC patterns. We provide novel evidence of graded changes along two main organisational axes. Specifically, the LIFG was characterized by an anterior-posterior gradient, which could reflect a shift in function from perceptually-driven processing to task-oriented control processes. Moreover, we revealed a dorsal-ventral shift in FC that is consistent with the idea that domain-specificity is a core principle underpinning functional organisation of the LIFG. These gradients were replicated across task-free and task-constrained FC measures, suggesting that a similar fundamental organisation underpins both mental states.

neuroscience↗

bioRxiv2021

The Ventrolateral Anterior Temporal Lobe is Commonly Engaged by Both Mental State Inference and Semantic Association Tasks

A key challenge for neurobiological models of social cognition is to elucidate whether brain regions are specialised for that domain. In recent years, discussion surrounding the role of anterior temporal regions epitomises such debates; some argue the anterior temporal lobe (ATL) is part of a domain-specific network for social processing, while others claim it comprises a domain-general hub for semantic representation. In the present study, we used ATL-optimised fMRI to map the contribution of different ATL structures to a variety of paradigms frequently used to probe a crucial social ability, namely theory of mind (ToM). Using multiple tasks enables a clearer attribution of activation to ToM as opposed to idiosyncratic features of stimuli. Further, we directly explored whether these same structures are also activated by a non-social task probing semantic representations. We revealed that common to all of the tasks was activation of a key ventrolateral ATL region that is often invisible to standard fMRI. This constitutes novel evidence in support of the view that the ventrolateral ATL contributes to social cognition via a domain-general role in semantic processing, and against claims of a specialised social function.

neuroscience↗

bioRxiv2021

Establishing a Role of the Semantic Control Network in Social Cognitive Processing: A Meta-analysis of Functional Neuroimaging Studies

Most leading models of socio-cognitive processing devote little discussion to the nature and neuroanatomical correlates of cognitive control mechanisms. Recently, it has been proposed that the regulation of social behaviours could rely on brain regions specialised in the controlled retrieval of semantic information, namely the anterior inferior frontal gyrus (IFG) and posterior middle temporal gyrus. Accordingly, we set out to investigate whether the neural activation commonly found in social functional neuroimaging studies extends to these semantic control regions. We conducted five coordinate-based meta-analyses to combine results of over 500 fMRI/PET experiments and identified the brain regions consistently involved in semantic control, as well as four social abilities: theory of mind, trait inference, empathy and moral reasoning. This allowed an unprecedented parallel review of the neural networks associated with each of these cognitive domains. The results confirmed that the anterior left IFG region involved in semantic control is reliably engaged in all four social domains. This suggests that social cognition could be partly regulated by the neurocognitive system underpinning semantic control.

neuroscience↗