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Biology subjects

DiMaggio, P. A.

Publications and source records attributed to DiMaggio, P. A..

2 recordsLinked to original sources

Bridging biomolecular modalities for knowledge transfer in bio-language models

In biology, messenger RNA (mRNA) plays a crucial role in gene expression and protein synthesis. Accurate predictive modeling of mRNA properties can greatly enhance our understanding and manipulation of biological processes, leading to advancements in medical and biotechnological applications. Utilizing bio-language foundation models allows for leveraging large-scale pretrained knowledge, which can significantly improve the efficiency and accuracy of these predictions. However, mRNA specific foundation models are notably limited posing challenges for efficient predictive modeling in mRNA-focused tasks. In contrast, DNA and protein modalities have numerous general-purpose foundation models trained on billions of sequences. This paper explores the potential for adaptation of existing DNA and protein bio-language models for mRNA-focused tasks. Through experiments using various mRNA datasets curated from both public domain and internal proprietary database, we demonstrate that pre-trained DNA and protein models can be effectively transferred for mRNA-focused tasks using various adaptation techniques such as probing, full-rank, and low-rank finetuning. In addition, we identify key factors that influence successful adaptation, offering guidelines on when general-purpose DNA and protein models are likely to perform well for mRNA-focused tasks. We further assess the impact of model size on adaptation efficacy, finding that medium-scale models often outperform larger ones for cross-modal knowledge transfer. We conclude that by leveraging the interconnectedness of DNA, mRNA, and proteins, as outlined by the central dogma of molecular biology, the knowledge in foundation models can be effectively transferred across modalities, significantly enhancing the repertoire of computational tools available for mRNA analysis.

bioinformatics↗

An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation

ADP-ribosylation is integral to a diverse range of cellular processes such as DNA repair, chromatin regulation and RNA processing. However, proteome-wide investigation of its cellular functions has been limited due to numerous technical challenges including the complexity of the poly(ADP-ribose) (PAR) chains, low abundance of the modification and lack of sensitive enrichment methods. To facilitate live-cell profiling of ADP-ribosylated proteins, we show that 2-alkyne-adenosine (2YnAd) is metabolically incorporated in mammalian cells and enables fluorescent detection and robust affinity enrichment of the modified proteins. We then present an integrated chemical biology approach that involves simultaneous metabolic incorporation of 2YnAd and the previously reported 6-alkyne-adenosine (6YnAd) in live cells followed by click chemistry with a capture reagent to facilitate highly sensitive and comprehensive enrichment of the modified proteins. By combining this dual metabolic labelling strategy with the tandem mass tag (TMT) isobaric mass spectrometry, we have quantified the responses of thousands of endogenous proteins to clinical PARP inhibitors Olaparib and Rucaparib. Our study provides insight into the wider scope of PARP targets and will help to advance further characterisation of their functional roles.

biochemistry↗