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Biology subjects

Devitt, A.

Publications and source records attributed to Devitt, A..

2 recordsLinked to original sources

Episodic and semantic memory contributions to imagination and creativity

The ability to generate novel creative ideas (divergent thinking) is closely linked with our ability to imagine novel future events (episodic simulation). Here, we employed an individual differences approach to examine whether divergent thinking and episodic simulation are differentially associated with episodic and semantic retrieval ability. In response to object word cues, participants generated meanings and definitions (semantic memory), remembered a past event (episodic memory), imagined a novel future event (episodic simulation), or generated novel uses (divergent thinking). Replicating previous findings, divergent thinking ability was predicted by the number of episodic details generated during episodic simulation. When directly comparing episodic and semantic memory, the strongest predictor of divergent thinking was semantic memory. In contrast, episodic simulation ability was predicted by both episodic and semantic memory. We interpret these findings as support for the semantic scaffold hypothesis of imagination, according to which semantic memory provides the necessary scaffold or framework for flexible expressions of cognition such as divergent thinking and episodic simulation. As episodic simulation, relative to divergent thinking, was associated with both episodic and semantic retrieval, these findings are taken to reflect common reliance on event construction processes recruited during both episodic remembering and imagining.

neuroscience↗

Unravelling the glycome in human intervertebral disc degeneration: Aberrant glycosylation modulates inflammation and metabolism.

Intervertebral disc (IVD) degeneration is one of the major contributing causes of low back pain (LBP), a common health issue that imposes a significant socio-economic burden on society. Previous work has demonstrated a dysregulated glycome in animal models of IVD degeneration; however, the role of glycosylation in pathogenesis is unknown. The objective of this study was to characterise altered glycan expression in IVD degeneration and elucidate the functional role of this response. Glycans in human healthy (n=6) and degenerated IVD (n=6) were examined through UPLC-MS and MALDI-IMS. These findings were correlated with proteomic analysis by LC-MS and functional in vitro studies using RNA sequencing. IVD degeneration was associated with a hypersialylated N-glycome, predominantly -2,6 linked sialic acid. Confirming hypersialylation, we investigated sialylations functional role through mechanistic studies using a sialylation inhibitor (3Fax-peracetyl Neu5Ac). Sialylation inhibition in vitro modulated inflammatory and metabolic pathways, demonstrating a functional role for glycosylation in IVD degeneration. Brief summaryIVD degeneration is associated with altered glycosylation, a potential target for new therapies.

bioengineering↗