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Biology subjects

Desmond, K.

Publications and source records attributed to Desmond, K..

2 recordsLinked to original sources

Multisensory learning binds modality-specific neurons into a cross-modal memory engram

Withdrawal StatementThe authors have withdrawn this manuscript. After conducting replication experiments and reanalysing the original data, the authors discovered that the voltage imaging results are not reproducible. Additional voltage imaging work by the authors and their collaborators has not produced robust signals. Furthermore, errors in the pipeline originally used for data analysis could have led to the contamination of data. A complete reanalysis by the authors of the voltage imaging data independently from the original pipeline did not replicate the original analysis. Although the authors have replicated the behavioural and connectomic data and consider that the general conclusions of the article are substantiated, the authors have no confidence in the voltage imaging data. The authors would like to apologize for any inconvenience caused to their scientific colleagues and the readers of the journal. The authors would like to thank Waddell lab members, A. Cook, A. Miriyala and M. Klappenbach, who were involved in the replication experiments but are not authors of the original paper and M. Hoffmann, S. Thornquist and G. Maimon of Rockefeller University for identifying possible errors in the voltage data processing. All authors agree with the withdrawal, with the exception of P. F. Jacob who did not respond to correspondence. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.

neuroscience↗

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma

Recurrence of solid tumors renders patients vulnerable to a distinctly advanced, highly treatment-refractory disease state that has an increased mutational burden and novel oncogenic drivers not detected at initial diagnosis. Improving outcomes for recurrent cancers requires a better understanding of cancer cell populations that expand from the post-therapy, minimal residual disease (MRD) state. We profiled barcoded tumor stem cell populations through therapy at tumor initiation/engraftment, MRD and recurrence in our therapy-adapted, patient-derived xenograft models of glioblastoma (GBM). Tumors showed distinct patterns of recurrence in which clonal populations exhibited either an a priori, pre-existing fitness advantage, or a priori equipotency fitness acquired through therapy. Characterization of the MRD state by single-cell and bulk RNA sequencing revealed a tumor-intrinsic immunomodulatory signature with strong prognostic significance at the transcriptomic level and in proteomic analysis of cerebrospinal fluid (CSF) collected from GBM patients at all stages of disease. Our results provide insight into the innate and therapy-driven dynamics of human GBM, and the prognostic value of interrogating the MRD state in solid cancers.

cancer biology↗