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Dayton, J. N.

Publications and source records attributed to Dayton, J. N..

2 recordsLinked to original sources

iLAM: imaging Locomotor Activity Monitor for circadian phenotyping of large-bodied flying insects

Practical ToolsO_LIHistorically, most insect chronoecological research has used direct observations, cameras, or infrared beam-based monitors to quantify movement across timed intervals. Although some alternative DIY systems are cheaper than the current standard locomotor activity monitor, these options remain complicated to build and/or computationally intensive. C_LIO_LIWe developed the imaging Locomotor Activity Monitor (iLAM), an affordable ([~] $75 USD/unit) system for activity quantification. The iLAM utilizes a Raspberry Pi Zero W computer and night-vision camera inside a flight cage to photograph a population of insects at user-defined intervals. Open-source, modular R-scripts process the images and output a file containing the number, size, coordinate location, and timing for all movements (blobs) identified between consecutive images. Output can be analyzed directly or converted into the standard TriKinetics DAM format. C_LIO_LIWe demonstrated the flexibility and power of the iLAM system by comparing diel and circadian activity of different insect species (fireflies: Photinus marginellus, P. greeni, P. obscurellus), ecotypes (moths: Ostrinia nubilalis), and sexes (moths: O. nubilalis). Data captured by only six iLAMs ($450) identified that peak activity of O. nubilalis females (AZT: 19.2 hr) occurs significantly earlier than males (22.0 hr). Additionally, male moths from a univoltine population exhibited a significantly shorter endogenous period length (AZT: 21.3 hr) than males from a bivoltine genetic background (22.6 hr). C_LIO_LIThe iLAM will serve as a valuable tool for future researchers seeking to measure locomotor activity across diverse species, sexes, and populations in constant and changing environments. C_LI

animal behavior and cognition↗

Transposable element-mediated rearrangements are prevalent in human genomes

Transposable elements constitute about half of human genomes, and their role in generating human variation through retrotransposition is broadly studied and appreciated. Structural variants mediated by transposons, which we call transposable element-mediated rearrangements (TEMRs), are less well studied, and the mechanisms leading to their formation as well as their broader impact on human diversity are poorly understood. Here, we identify 493 unique TEMRs across the genomes of three individuals. While homology directed repair is the dominant driver of TEMRs, our sequence-resolved TEMR resource allows us to identify complex inversion breakpoints, triplications or other high copy number polymorphisms, and additional complexities. TEMRs are enriched in genic loci and can create potentially important risk alleles such as a deletion in TRIM65, a known cancer biomarker and therapeutic target. These findings expand our understanding of this important class of structural variation, the mechanisms responsible for their formation, and establish them as an important driver of human diversity.

genomics↗