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Cosma, C.

Publications and source records attributed to Cosma, C..

2 recordsLinked to original sources

Local interaction networks reconstructed from global biodiversity data improve pollinator restoration decision making

Global pollinator declines threaten the health of ecosystems and food systems, underscoring the urgency of conservation actions such as habitat restoration. However, data gaps on plant use among pollinators continue to limit reliable design of restoration plant mixes. To address this, we present NECTAR (Network-Enhanced Conservation Tool for Analysis and Recommendation), a new modular framework that integrates multiple data modalities - including species distributions, phenological metrics, and phylogenetic data - to infer flower visitation and host plant interactions from spatial, temporal, and phylogenetic overlap, generating spatially explicit plant-insect interaction networks that guide planting recommendations for pollinator habitat restoration. We demonstrate the utility of NECTAR by generating a large plant-insect metaweb across California, comprising 2,473,729 spatially explicit interactions that included 3,792 pollinator species and 4,363 native plant species. NECTAR achieved high interaction recall across withheld interactions and independent datasets, substantially outperforming null models and matching or exceeding values reported in comparable studies. NECTAR's data-driven plant mix recommendations are predicted to support up to 2.4 times more pollinator species compared to existing resources and random selection of plants. This optimization facilitates the inclusion of multiple goals and constraints, and provides complementary decision-making information to existing resources. NECTAR offers a scalable, evidence-based framework for translating increasingly available global biodiversity data into locally actionable restoration guidance, with broad potential to improve pollinator habitat restoration worldwide.

ecology↗

Regulation of PDGF-BB Signaling in Placental Pericytes by Soluble PDGFRβ Isoforms: Implications for Fetoplacental Vascular Development

ABSTRACT/SUMMARYVascular remodeling within the developing fetus and placenta is essential for supporting the growth and function of emerging tissues and organs. Pericytes (PCs) play a central role in stabilizing and maturing microvascular networks by extending along endothelial cells (ECs) and reinforcing vessel integrity. In the placenta, as in other organs, PC-EC communication is mediated in part by platelet-derived growth factor-BB (PDGF-BB) signaling, which governs PC differentiation, proliferation, migration, and survival, ultimately enabling their recruitment and retention along capillaries. In this study, we identified progressive PC investment along feto-placental capillaries in both murine and human tissues across gestation, supported by morphological and molecular evidence. Placental PCs displayed phenotypic heterogeneity comparable to that observed in the brain and heart, suggesting conserved diversity across organ systems. In addition to characterizing PC dynamics, we examined the expression of recently identified soluble PDGF Receptor-{beta} (sPDGFR{beta}) isoforms. These variants were detected at the protein and transcript levels in mouse and human placentas, as well as in a murine trophoblast-embryonic stem cell (TESC) differentiation model that recapitulates aspects of early placental vascular development. Within this model, sPDGFR{beta} expression was independent of ADAM10 activity and exogenous growth factors during early vessel formation but was markedly upregulated during hypoxia. To assess how elevated sPDGFR{beta} might influence PDGF-BB signaling, we exposed TESCl-derived vascular networks to excess PDGF-BB with or without a sPDGFR{beta} mimetic. PDGF-BB alone reduced full-length PDGFR{beta} levels while increasing receptor phosphorylation, consistent with known ligand-induced regulatory mechanisms. Inclusion of the sPDGFR{beta} mimetic shifted these responses toward baseline, suggesting a potential modulatory or feedback role for soluble receptor variants. Together, these findings demonstrate that PCs are progressively recruited to placental capillaries and exhibit diverse phenotypes during development, and that soluble PDGFR{beta} isoforms may modulate PDGF-BB signaling in a manner sensitive to oxygen tension. Understanding these mechanisms provides insight into the regulation of placental vascular maturation and may inform strategies to improve human health by targeting disorders rooted in impaired placental development.

developmental biology↗