Biology subjects

Correa-Gallegos, D.

Publications and source records attributed to Correa-Gallegos, D..

2 recordsLinked to original sources

bioRxiv2026

Cardiovascular risk gene HDAC9 drives maladaptive vascular remodeling after arterial injury

Arterial restenosis following balloon angioplasty - a procedure performed to re-establish vessel patency in atherosclerotic cardiovascular disease - remains a major clinical challenge and a key barrier to durable revascularization. Endothelial denudation induced by angioplasty triggers an inflammatory cascade that drives vascular smooth muscle cell (VSMC) proliferation, migration, and phenotypic switching, culminating in neointimal hyperplasia and restenosis1. Human genetics-guided target discovery has proven more effective than non-guided approaches in revealing causal pathways of complex cardiovascular traits2. Genetic variants at Histone Deacetylase 9 (HDAC9) are a major risk factor for cardiovascular disease3,4 and is associated with increased carotid intima-media thickness and modulation of VSMC phenotype4. Here, using an experimental model of arterial injury that faithfully mirrors the vascular response to balloon angioplasty in humans, we show that HDAC9 drives maladaptive remodeling of the arterial wall following vascular injury.

physiology↗

bioRxiv2024

A single cell and spatial genomics atlas of human skin fibroblasts in health and disease

Fibroblasts are critical cells that shape the architecture and cellular ecosystems in multiple tissues. Understanding fibroblast heterogeneity and their spatial context in health and disease has enormous clinical relevance. In this study, we constructed a spatially-resolved atlas of human skin fibroblasts from healthy skin and 23 skin disorders. We define 6 major skin fibroblast populations in health and a further three skin disease-specific fibroblast subtypes, and demonstrate the fibroblast composition in different types of skin disease. We characterise a human-specific fibroblastic reticular cell (FRC)-like subtype in the skin perivascular niche and postulate their origin from prenatal skin lymphoid tissue organiser (LTo)-like cells. We also show that inflammatory myofibroblasts (IL11+MMP1+CXCL5+IL7R+) are a conserved fibroblast subtype in inflammatory disorders and cancers across multiple human tissues. We provide a harmonised nomenclature for skin fibroblasts that integrates previous findings from human skin and other tissues.

cell biology↗