Biology subjects

Cole, T. J.

Publications and source records attributed to Cole, T. J..

2 recordsLinked to original sources

bioRxiv2018

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Cranial growth and development affects the closely related traits of head circumference (HC) and intracranial volume (ICV). Here we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic determinants of ICV. Investigating up to 46,000 children and adults of European descent, we identify association with final HC and/or final ICV+HC at 9 novel common and low-frequency loci, illustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth. The largest effects are reported for low-frequency variants within TP53, with 0.5 cm wider heads in increaser-allele carriers versus non-carriers during mid-childhood.

genetics↗

bioRxiv2017

FUSTr: a tool to find gene Families Under Selection in Transcriptomes

FUSTr is a tool for finding genes in transcriptomic datasets under strong positive selection that automatically detects isoform designation patterns in transcriptome assemblies to maximize phylogenetic independence in downstream analysis. When applied to previously studied spider toxin families as well as simulated data, FUSTr successfully grouped coding sequences into proper gene families as well as correctly identified those under strong positive selection. FUSTr provides a tool capable of utilizing multi-processor high-performance computational facilities and is scalable for large transcriptomic biodiversity datasets.\n\nAvailabilityFUSTr is freely available under a GNU license and can be downloaded at https://github.com/tijeco/FUSTr.\n\nContactcoleti16@students.ecu.edu

bioinformatics↗