Capelli, I. | Search bioRxiv

bioRxiv2024

Apelin-13 alleviate inflammatory reaction of ischemia reperfusion in rat kidney transplantation via NF-kappa B signaling pathway

Withdrawal statementThis manuscript has been withdrawn after a request from the Dean of the Department of Medical and Surgical Sciences (DIMEC) at the University of Bologna. This manuscript constitutes a fraudulent submission by a third party impersonating Prof. Gaetano La Manna of said university. The email address listed for the corresponding author is invalid and not the institutional email address of Prof. La Manna, a member of DIMEC. Additionally, there are no other faculty members or researchers named Gaetano La Manna employed at the University of Bologna (UNIBO). Furthermore, the department (DIMES) associated with the publication in question was dissolved on December 31, 2022, and no longer exists. The individuals falsely listed as authors were not responsible for its submission and have no knowledge of or involvement in the work presented. Therefore, this article should not be cited as reference for this project.

cell biology↗

bioRxiv2018

Histological evidences of diabetic kidney disease precede clinical diagnosis

In the absence of a histhological diagnosis, persistent albuminuria is globally accepted as the main diagnostic criteria for diabetic kidney disease.\n\nIn the present retrospective study, we evaluated data from an Italian cohort of 42 diabetic deceased donors (mainly type 2 diabetes). Using kidney biopsies obtained at time of donation to evaluate single or double allocation based on Karpinski score, we determined the prevalence of histological lesions attributable to diabetes.\n\nAll 42 donors presented with normoalbuminuria and an estimated Glomerular Filtration Rate (CKD-EPI) > 60 ml/min/1.73m2. Of the 36 patients with available kidney biopsy, one was non interpretable and 32 had histopathological lesions consistent with diabetic kidney disease and encompassing all histological classes.\n\nThus, we found a relatively high proportion of histologically proven diabetic kidney disease that was clinically undiagnosed as none of the patient had significant albuminuria and eGFR <60 cc/min/1.73 m2. Our data support the need to implement routine kidney biopsies in normoalbuminuric diabetic subjects in early stages of Chronic Kidney Disease. As others have shown that histological lesions associated with diabetic kidney disease predict disease progression, such strategy may help to risk stratify patients and may guide therapeutic decisions at early disease stages.

scientific communication and education↗