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Calinawan, A. P.

Publications and source records attributed to Calinawan, A. P..

4 recordsLinked to original sources

Decomprolute: A benchmarking platform designed for multiomics-based tumor deconvolution

Tumor deconvolution is a reliable way to disentangle the diverse cell types that comprise solid tumors. To date, however, both the algorithms developed to deconvolve tumor samples, and the gold standard datasets used to assess the algorithms are geared toward the analysis of gene expression (e.g., RNA-seq) rather than protein levels in tumor cells. While gene expression is less expensive to measure, protein levels provide a more accurate view of immune markers. To facilitate the development as well as improve the reproducibility and reusability of multi-omic deconvolution algorithms, we introduce Decomprolute, a Common Workflow Language framework that leverages containerization to compare tumor deconvolution algorithms across multiomic data sets. Decomprolute incorporates the large-scale multiomic data sets produced by the Clinical Proteomic Tumor Analysis Consortium (CPTAC), which include matched mRNA expression and proteomic data from thousands of tumors across multiple cancer types to build a fully open-source, containerized proteogenomic tumor deconvolution benchmarking platform. The platform consists of modular architecture and it comes with well-defined input and output formats at each module. As a result, it is robust and extendable easily with additional algorithms or analyses. The platform is available for access and use at http://pnnl-compbio.github.io/decomprolute. MotivationTo provide a comprehensive platform for algorithm developers and researchers to benchmark and run tumor deconvolution algorithms on multiomic data.

cancer biology↗

BayesDeBulk: A Flexible Bayesian Algorithm for the Deconvolution of Bulk Tumor Data

To understand immune activation and evasion mechanisms in cancer, one crucial step is to characterize the composition of immune and stromal cells in the tumor microenvironment (TME). Deconvolution analysis based on bulk transcriptomic data has been used to estimate cell composition in TME. However, these algorithms are sub-optimal for proteomic data, which has hindered research in the rapidly growing field of proteogenomics. Moreover, with the increasing prevalence of multi-omics studies, there is an opportunity to enhance deconvolution analysis by utilizing paired proteomic and transcriptomic profiles of the same tissue samples. To bridge these gaps, we propose BayesDeBulk, a new method for estimating the immune/stromal cell composition based on bulk proteomic and gene expression data. BayesDeBulk utilizes the information of known cell-type-specific markers without requiring their absolute abundance levels as prior knowledge. We compared BayesDeBulk with existing tools on synthetic and real data examples, demonstrating its superior performance and versatility. AvailabilitySoftware available at http://www.BayesDeBulk.com/ ContactFor any information, please contact francesca.petralia@mssm.edu

bioinformatics↗

Prioritization prostate cancer to immune checkpoint therapy by ranking tumors along IFN-γ axis and identification of immune resistance mechanisms

We propose priotirization of prostate cancer patients to PD-L1 checkpoint therapy by assessing activity of IFN-{gamma}/PD-L1 signaling in tumor from transcriptional profile. To this end, we introduced a new approach for inferring pathway activity and suppression (IPAS) by assessing significance of positioning pathways genes expression levels at top (activation) or bottom (suppression) in gene expression profile of a given tumor. By ordering tumors along IFN-{gamma}/PD-L1 axis, we determined distinct "IFN-{gamma}-depleted" and "IFN-{gamma}-enriched" immune subtypes, genes involved in immune evasion and potential targets for combination therapy. Using IPAS scoring method, we proposed biomarker panels for accurate ranking tumors along IFN-{gamma}/PD-L1 axis.

bioinformatics↗

ProTrack: An Interactive Multi-Omics Data Browser for Proteogenomic Studies

The Clinical Proteomic Tumor Analysis Consortium (CPTAC) initiative has generated extensive multi-omics data resources of deep proteogenomic profiles for multiple cancer types. To enable the broader community of biological and medical researchers to intuitively query, explore, and download data and analysis results from various CPTAC projects, we built a prototype user-friendly web application called "ProTrack" with the CPTAC clear cell renal cell carcinoma (ccRCC) data set (http://ccrcc.cptac-data-view.org). Here we describe the salient features of this application which provides a dynamic, comprehensive, and granular visualization of the rich proteogenomic data. Statement of SignificanceThe CPTAC initiative (https://proteomics.cancer.gov/) has generated multi-omics data for multiple cancer types to understand the proteogenomic aberrations of these malignancies. Collectively this effort has so far produced a large data resource for the research community, including high-throughput profiles for proteome, phosphoproteome, whole exome, whole genome, transcriptome, and DNA methylome. To make this valuable data-resource useful to the larger research community, there is a pressing need for development of user-friendly, readily accessible, and easily shared analytic and visualization tools for aligning multi-omics data and exploring alterations in key cancer genes, to drive and support new biological hypotheses. To bridge this gap, we have developed CPTAC ProTrack, an interactive web application which uses a multilayered, client-server architecture in order to deliver an interactive web experience to any user of a modern web-browser. This tool is intentionally designed accessible for researchers, biologists, and clinicians who are interested in multi-omic data without any need to code.

bioinformatics↗