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Biology subjects

Buturovic, L.

Publications and source records attributed to Buturovic, L..

2 recordsLinked to original sources

A novel method for classification of tabular data using convolutional neural networks

Convolutional neural networks (CNNs) represent a major breakthrough in image classification. However, there has not been similar progress in applying CNNs, or neural networks of any kind, to classification of tabular data. We developed and evaluated a novel method, TAbular Convolution (TAC), for classification of such data using CNNs by transforming tabular data to images and then classifying the images using CNNs. The transformation is performed by treating each row of tabular data (i.e., vector of features) as an image filter (kernel), and applying the filter to a fixed base image. A CNN is then trained to classify the filtered images. We applied TAC to classification of gene expression data derived from blood samples of patients with bacterial or viral infections. Our results demonstrate that off-the-shelf ResNet can classify the gene expression data as accurately as the current non-CNN state-of-the-art classifiers.

bioinformatics↗

A machine learning method for subgroup analysis of randomized controlled trials

We developed a machine learning method for subgroup analyses of randomized controlled trials (RCT), and applied it to the results of the SPRINT RCT for treatment of hypertension. To date, the subgroup analyses mostly focused on detecting associations between certain factors and outcome, in the hope that the results will point out biologically (for example, carriers of a certain mutation) or clinically (for example, smokers) distinct subgroups with different outcomes. This seldom worked in the sense of re-launching the intervention for the detected subgroup only and successfully treating it. In contrast, we propose an empirical and general method to develop a predictive multivariate classifier using the RCT outcomes and baseline data. The classifier identifies patients likely to benefit from the intervention, is not limited to a single factor of interest, and is ready for validation in a subsequent pivotal trial. We believe this approach has a better chance of succeeding in identifying the relevant subgroups because of increased accuracy made possible by the use of multiple predictor variables, and opportunity to use advanced machine learning. The method effectiveness is demonstrated by the analysis of the SPRINT trial.

bioinformatics↗