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Burgstaller-Muehlbacher, S.

Publications and source records attributed to Burgstaller-Muehlbacher, S..

2 recordsLinked to original sources

Distinguishing Felsenstein zone from Farris zone using neural networks

Maximum likelihood and maximum parsimony are two key methods for phylogenetic tree reconstruction. Under certain conditions, each of these two methods can perform more or less efficiently than the other. We show that a neural network can efficiently distinguish between four-taxon alignments that were evolved under conditions conducive to long-branch attraction, or long-branch repulsion. The feedback from the neural network can be used to select the most efficient tree reconstruction method yielding increased accuracy, when compared to a rigid choice of reconstruction methods. When applied to the contentious case of Strepsiptera evolution, our method agrees with the current scientific view.

evolutionary biology

Wikidata as a FAIR knowledge graph for the life sciences

Wikidata is a community-maintained knowledge base that epitomizes the FAIR principles of Findability, Accessibility, Interoperability, and Reusability. Here, we describe the breadth and depth of biomedical knowledge contained within Wikidata, assembled from primary knowledge repositories on genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases. We built a collection of open-source tools that simplify the addition and synchronization of Wikidata with source databases. We furthermore demonstrate several use cases of how the continuously updated, crowd-contributed knowledge in Wikidata can be mined. These use cases cover a diverse cross section of biomedical analyses, from crowdsourced curation of biomedical ontologies, to phenotype-based diagnosis of disease, to drug repurposing.

bioinformatics