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Bertke, A. S.

Publications and source records attributed to Bertke, A. S..

2 recordsLinked to original sources

Translational insights into canine dorsal root ganglia cell types using cross-species comparisons

Chronic pain accounts for nearly half of owner-reported canine euthanasia decisions, yet dogs remain underutilized as a large-animal model for studying pain and developing translational therapeutics. Here, we present a canine dorsal root ganglion (DRG) cell atlas generated from six donors, representing five breeds, both sexes, and three spinal segments. Our dataset comprises 3,026 neurons and 11,734 non-neuronal cells and resolves 15 neuronal subtypes that map cleanly onto A- and C-fiber classes. We further identify eight major non-neuronal subtypes, including glial, vascular, and immune populations and characterize neuronal and non-neuronal expression of physiologically relevant neuropeptides, receptors, and ion channels. We identify region-specific differences in subtype composition between lumbar and sacral DRGs, with transcriptional programs suggestive of enhanced tactile-associated signaling in lumbar DRGs and heightened nociception-associated signaling in sacral DRGs. Cross-species comparisons reveal that canine DRG subtypes are broadly conserved with human and mouse, while also exhibiting canine-specific and canine-human shared molecular features relevant for translation. Together, this atlas serves as a valuable resource for understanding canine sensory neurobiology, comparing DRG organization across mammals, and leveraging dogs as a translational model for pain research and therapeutic development.

neuroscience↗

SARS-CoV-2 Infects Peripheral and Central Neurons of Mice Before Viremia, Facilitated by Neuropilin-1

Neurological symptoms associated with COVID-19, acute and long-term, suggest SARS-CoV-2 affects both central and peripheral nervous systems. Although studies have shown olfactory and hematogenous entry into the brain and neuroinflammation, little attention has been paid to the susceptibility of the peripheral nervous system to infection or to alternative routes of CNS invasion. We show that neurons in the central and peripheral nervous system are susceptible to productive infection with SARS-CoV-2. Infection of K18-hACE2 mice, wild-type mice, golden Syrian hamsters, and primary neuronal cultures demonstrate viral RNA, protein, and infectious virus in peripheral nervous system neurons and satellite glial cells, spinal cord, and specific brain regions. Moreover, neuropilin-1 facilitates SARS-CoV-2 neuronal infection. Our data show that SARS-CoV-2 rapidly invades and establishes a productive infection in the peripheral and central nervous system via direct invasion of neurons prior to viremia, which may underlie some cognitive and sensory symptoms associated with COVID-19.

neuroscience↗