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Benjamin M Good

Publications and source records attributed to Benjamin M Good.

4 recordsLinked to original sources

CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.

CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer (www.civicdb.org) describing the therapeutic, prognostic, and diagnostic relevance of inherited and somatic variants of all types. CIViC is committed to open source code, open access content, public application programming interfaces (APIs), and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

Cancer Biology

Knowledge.Bio: A Web application for exploring, building and sharing webs of biomedical relationships mined from PubMed

Knowledge.Bio is a web platform that enhances access and interpretation of knowledge networks extracted from biomedical research literature. The interaction is mediated through a collaborative graphical user interface for building and evaluating maps of concepts and their relationships, alongside associated evidence. In the first release of this platform, conceptual relations are drawn from the Semantic Medline Database and the Implicitome, two compleme ntary resources derived from text mining of PubMed abstracts.\n\nAvailability-- Knowledge.Bio is hosted at http://knowledge.bio/ and the open source code is available at http://bitbucket.org/sulab/kb1/.\n\nContact-- asu@scripps.edu; bgood@scripps.edu

Bioinformatics

Citizen Science for Mining the Biomedical Literature

I.Biomedical literature represents one of the largest and fastest growing collections of unstructured biomedical knowledge. Finding critical information buried in the literature can be challenging. In order to extract information from freeflowing text, researchers need to: 1. identify the entities in the text (named entity recognition), 2. apply a standardized vocabulary to these entities (normalization), and 3. identify how entities in the text are related to one another (relationship extraction). Researchers have primarily approached these information extraction tasks through manual expert curation, and computational methods. We have previously demonstrated that named entity recognition (NER) tasks can be crowdsourced to a group of nonexperts via the paid microtask platform, Amazon Mechanical Turk (AMT); and can dramatically reduce the cost and increase the throughput of biocuration efforts. However, given the size of the biomedical literature even information extraction via paid microtask platforms is not scalable. With our web-based application Mark2Cure (http://mark2cure.org), we demonstrate that NER tasks can also be performed by volunteer citizen scientists with high accuracy. We apply metrics from the Zooniverse Matrices of Citizen Science Success and provide the results here to serve as a basis of comparison for other citizen science projects. Further, we discuss design considerations, issues, and the application of analytics for successfully moving a crowdsourcing workflow from a paid microtask platform to a citizen science platform. To our knowledge, this study is the first application of citizen science to a natural language processing task.

Bioinformatics

Wikidata: A platform for data integration and dissemination for the life sciences and beyond

Wikidata is an open, Semantic Web-compatible database that anyone can edit. This data commons provides structured data for Wikipedia articles and other applications. Every article on Wikipedia has a hyperlink to an editable item in this database. This unique connection to the worlds largest community of volunteer knowledge editors could help make Wikidata a key hub within the greater Semantic Web. The life sciences, as ever, faces crucial challenges in disseminating and integrating knowledge. Our group is addressing these issues by populating Wikidata with the seeds of a foundational semantic network linking genes, drugs and diseases. Using this content, we are enhancing Wikipedia articles to both increase their quality and recruit human editors to expand and improve the underlying data. We encourage the community to join us as we collaboratively create what can become the most used and most central semantic data resource for the life sciences and beyond.

Bioinformatics