Glia multitask to compensate for neighboring glial cell dysfunction
As glia mature, they undergo glial tiling to abut one another without invading each others boundaries. Upon the loss of the secreted neurotrophin Spatzle3 (Spz3), Drosophila cortex glia transform morphologically and lose their intricate interactions with neurons and surrounding glial subtypes. Here, we reveal that all neighboring glial cell types (astrocytes, ensheathing glia, and subperineurial glia) react by extending processes into the previous cortex glial territory to compensate for lost cortex glial function and reduce the buildup of neuronal debris. However, the loss of Spz3 alone is not sufficient for glia to cross their natural borders, as blocking CNS growth via nutrient-restriction blocks the aberrant infiltration induced by the loss of Spz3. Surprisingly, even when these neighboring glia divert their cellular resources beyond their typical borders to take on new compensatory roles, they are able to multitask to continue to preserve their own normal functions to maintain CNS homeostasis. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=136 SRC="FIGDIR/small/611719v1_ufig1.gif" ALT="Figure 1"> View larger version (53K): org.highwire.dtl.DTLVardef@1a1a884org.highwire.dtl.DTLVardef@3ea222org.highwire.dtl.DTLVardef@676b7org.highwire.dtl.DTLVardef@5c21d6_HPS_FORMAT_FIGEXP M_FIG C_FIG