Biology subjects

Bausek, N.

Publications and source records attributed to Bausek, N..

4 recordsLinked to original sources

bioRxiv2025

Effect of combined Respiratory Muscle Training on Sleep and Cardiovascular Biometrics in a non-clinical cohort

Study objectivesSleep disruption is a growing health problem, affecting a significant portion of the adult population worldwide. Insufficient sleep has various short- and long-term consequences, including an elevated risk of cardiovascular and metabolic diseases. Previous research has demonstrated that resistive respiratory muscle training (RMT) can enhance both sleep quality and cardiovascular health in individuals diagnosed with obstructive sleep apnea, underscoring its efficacy as a non-pharmacological therapeutic strategy for this patient group. However, the effects of RMT on sleep and cardiovascular parameters have not been investigated in non-clinical populations. MethodsThis prospective study investigated the effects of combined inspiratory and expiratory RMT (cRMT) on sleep parameters and cardiovascular biometrics, specifically heart rate variability (HRV), in a non-clinical adult cohort. Utilizing a wearable device for remote data collection, this randomized controlled trial included 67 participants divided into good and poor sleeper groups based on historical sleep data. During a five-week intervention period, participants in the intervention group underwent cRMT using a Breather Fit device, while control group participants did not receive the intervention. ResultsStudy findings demonstrate a significant increase in overnight HRV metrics during the intervention period compared to the baseline, indicating improved autonomic cardiac function. However, no significant changes were observed in any parameters of sleep quality. ConclusionThese results suggest that cRMT may enhance cardiovascular health by improving autonomic function in non-clinical populations without directly affecting sleep quality. This study underscores the potential of RMT as a non-pharmacological intervention to improve cardiovascular health, warranting further investigation in future studies. Brief summaryO_LICurrent Knowledge/Study Rationale: Insufficient, disrupted, or ineffective sleep is prevalent and can increase the risk of developing cardiovascular disease (CVD). While respiratory muscle training has been found effective in improving sleep and cardiovascular parameters in sleep apnea, its effect in healthy people with or without sleep issues is unknown. C_LIO_LIStudy Impact: This study demonstrates significant benefits of RMT on CVD metrics including HR and HRV, indicating improved autonomic cardiac function. These findings highlight the potential of RMT as a non-pharmacological intervention to improve cardiovascular health. C_LI

physiology↗

bioRxiv2019

Respiratory Intervention Techniques Increase Selection Rate for Special Forces

O_LISpecial Forces Selection Rates have declined over recent years, partly due to reduced fitness rates of applications\nC_LIO_LIPostural changes incurred prior to the recruitment may contribute to compromised respiratory function, resulting in fatigue, overexertion, and Selection Course failure\nC_LIO_LIPerformance breathing training and respiratory muscle strengthening can reverse impaired respiratory function and optimize cardiopulmonary fitness.\nC_LIO_LIIn this study, a 6-week intervention program including performance breathing training improved fitness and performance of SF Selection Course participants.\nC_LIO_LIThe intervention program including performance breathing training increased the SF Selection Course pass rate from 0% to 30%, compared to prior years.\nC_LI

physiology↗

bioRxiv2019

Respiratory Muscle Training Improves Speech and Pulmonary Function in COPD Patients in a Home Health Setting - a Pilot Study

Clinical Context and Key FindingsO_LIHome-based COPD managment, as provided by certified home-health providers, represents a cornerstone of patient care.\nC_LIO_LIResporatory muscle trainig (RMT) reduces symptoms of COPD and improves underlying respiratory muscle weakness, and may be a beneficial adjunct of standard of care treatment plans.\nC_LIO_LIThis 4 Week pilot study shows that RMT in combination with a standard of care home-based COPD management program can improve pulmonary and speech functions.\nC_LI

physiology↗

bioRxiv2017

A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability

In order for cells to sense and thus respond to their environment, they require transmembrane receptors, which bind extracellular ligands and then transduce this signal within the cell. A subset of receptors, with single-pass transmembrane domains are known as cytokine receptors and act via the Janus Kinase and Signal Transducer and Activator of Transcription (JAK/STAT) pathway. These receptors are essential for processes such as haematopoiesis, immune responses and tissue homeostasis. In order to transduce ligand activation, cytokine receptors must dimerise. However, mechanisms regulating their dimerisation are largely unknown. In order to better understand the processes regulating cytokine receptor levels, activity and dimerisation, we used the highly conserved JAK/STAT pathway in Drosophila, which acts via a single receptor, known as Domeless. We have performed a genome-wide RNAi screen in Drosophila cells, identifying MASK as a positive regulator of Domeless dimerisation and protein levels. We show that MASK is able to regulate JAK/STAT signalling both in vitro and in vivo. We go on to show that MASK is able to bind to Domeless via its Ankyrin repeat domains and alters the stability of the receptor. Finally, we extend our observations to the human homologue, ANKHD1, and demonstrate functional conservation, with ANKHD1 able to regulate JAK/STAT signalling and the levels of a subset of pathway receptors in human cells. Taken together, we have identified MASK as a conserved regulator of cytokine receptor levels, which may have implications for human health.

cell biology↗