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Barreto, C.

Publications and source records attributed to Barreto, C..

2 recordsLinked to original sources

Human herpesvirus 1 associated with epizootics in Belo Horizonte, Minas Gerais, Brazil

Human activity in sylvatic environments and resulting contact with wildlife, such as non-human primates (NHP), can lead to pathogen spillover or spillback. Both NHPs and humans host a variety of herpesviruses. While these viruses typically cause asymptomatic infections in their natural hosts, they can lead to severe disease or even death when they move into novel hosts. In early 2024, deaths of Callithrix penicillata, the black-tufted marmoset, were reported in an urban park in Belo Horizonte, Minas Gerais, Brazil. The epizootic was investigated in collaboration with CETAS/IBAMA and the Zoonoses Department of Belo Horizonte. Nine marmoset carcasses, and 4 sick marmosets were found in the park; the latter exhibited severe neurological symptoms and systemic illness before succumbing within 48 hours. Carcasses were tested for rabies virus and were all negative, and necropsy findings revealed widespread organ damage. In addition, the samples were tested for yellow fever virus, with negative results. Finally, molecular testing, viral isolation and phylogenetic analysis demonstrated human herpesvirus 1 (HHV-1) as the causative agent. The likely source of infection was human-to-marmoset transmission, facilitated by close interactions such as feeding and handling. This study highlights the risks of pathogen spillover between humans and nonhuman primates, emphasizing the need for enhanced surveillance and public awareness to mitigate future epizootics.

microbiology↗

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies. Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identified the upregulation of UBE2C, a gene that ensures the correct transition from metaphase to anaphase, across different primary tumor origins. Tissue microarray analysis of an independent BM patient cohort revealed that high expression of UBE2C was associated with decreased survival. UBE2C-driven orthotopic mouse models developed extensive leptomeningeal dissemination, likely due to increased migration and invasion. Early cancer treatment with dactolisib (dual PI3K/mTOR inhibitor) prevented the development of UBE2C-induced leptomeningeal metastases. Our findings reveal UBE2C as a key player in the development of metastatic brain disease and highlight PI3K/mTOR inhibition as a promising anticancer therapy to prevent late-stage metastatic brain cancer.

cancer biology↗