GENis, an open-source multi-tier forensic DNA information system
GENis is an open source multi-tier information system developed to run a forensic DNA database at local, regional and national levels.1 It was conceived as a highly customizable system, enforcing several security policies including: data encryption, double factor identification, structure of users roles and permissions, system-wide secure log auditing, non-repudiation protocols and a blockchain-based option to reinforce genetic profiles integrity. GENis is able to perform genetic profile queries of autosomal STRs and its design follows ENFSI2 and ISFG3 standards and recommendations. In this work, we present a summary of GENis architecture, the implemented matching rule definitions, and the Bayesian framework used to provide statistical significance of cold hits, that includes a new strategy to identify common contributors in mixture pairs.