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Baldo, M. V. C.

Publications and source records attributed to Baldo, M. V. C..

4 recordsLinked to original sources

A Computational Toolkit for Designing and Analysing Repeated Binary Choice Experiments

Adaptive human behaviour depends on the ability to detect regularities and probabilistic structures within a noisy environment. Repeated binary choice tasks, in which individuals predict one of two possible options, have long served as a fundamental tool for investigating learning, reward processing, and decision-making under uncertainty. However, traditional analyses of these tasks often rely on coarse measures such as accuracy or mean responses, overlooking the temporal information contained in behavioural sequences. This paper introduces a mathematical and computational framework to improve the analysis of binary choice data. First, we employ higher-order Markov chains to generate sequences with controlled probabilistic dependencies, allowing for a more subtle examination of how participants extract information and learn temporal structures. Presenting analytical methods derived from time series analysis (autocorrelation, cross---correlation, shifting probabilities and Markov reconstruction) to extract structural information from simulated data of prototypical behaviours, we demonstrate how these methods can identify distinct decisional patterns that remain hidden when using conventional approaches. Finally, we validate the proposed toolkit by applying it to empirical datasets. By revealing subtle but meaningful features of sequential decision-making, this framework enhances the interpretive power of probabilistic learning experiments. It provides researchers with tools to more accurately describe behavioural dynamics and deepens our understanding of the cognitive processes governing adaptive decisions in both healthy and clinical populations.

animal behavior and cognition↗

The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats.

Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. Ours results revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits (i.e., predator- and conspecific-responsive circuits).

neuroscience↗

The lateral periaqeductal gray and its role in controlling the opposite behavioral choices of predatory hunting and social defense.

Evasion from imminent threats and prey attack are opposite behavioral choices critical to survival. Curiously, the lateral periaqueductal gray (LPAG) has been implicated in driving both responses. The LPAG responds to social threats and prey hunting while also drives predatory attacks and active defense. However, the LPAG neural mechanisms mediating these behaviors remain poorly defined. Here, we investigate how the LPAG mediates the choices of predatory hunting and evasion from a social threat. Pharmacogenetic inhibition in Fos DD-Cre mice of neurons responsive specifically to insect predation (IP) or social defeat (SD) revealed that distinct neuronal populations in the LPAG drive the prey hunting and evasion from social threats. We show that the LPAG provides massive glutamatergic projection to the lateral hypothalamic area (LHA). Optogenetic inhibition of the LPAG-LHA pathway impaired IP but did not alter escape/attack ratio during SD. We also found that pharmacogenetic inhibition of LHAGABA neurons impaired IP, but did not change evasion during SD. The results suggest that the LPAG control over evasion to a social attack may be regarded as a stereotyped response depending probably on glutamatergic descending projections. On the other hand, the LPAG control over predatory behavior involves an ascending glutamatergic pathway to the LHA that likely influences LHAGABA neurons driving predatory attack and prey consumption. The LPAG-LHA path supposedly provides an emotional drive for prey hunting and, of relevance, may conceivably have more widespread control on the motivational drive to seek other appetitive rewards.

animal behavior and cognition↗

Exploration and recency as the main proximate causes of probability matching: a reinforcement learning analysis

Research has not yet reached a consensus on why humans match probabilities instead of maximise in a probability learning task. The most influential explanation is that they search for patterns in the random sequence of outcomes. Other explanations, such as expectation matching, are plausible, but do not consider how reinforcement learning shapes peoples choices.\n\nWe aimed to quantify how human performance in a probability learning task is affected by pattern search and reinforcement learning. We collected behavioural data from 84 young adult participants who performed a probability learning task wherein the majority outcome was rewarded with 0.7 probability, and analysed the data using a reinforcement learning model that searches for patterns. Model simulations indicated that pattern search, exploration, recency (discounting early experiences), and forgetting may impair performance.\n\nOur analysis estimated that 85% (95% HDI [76, 94]) of participants searched for patterns and believed that each trial outcome depended on one or two previous ones. The estimated impact of pattern search on performance was, however, only 6%, while those of exploration and recency were 19% and 13% respectively. This suggests that probability matching is caused by uncertainty about how outcomes are generated, which leads to pattern search, exploration, and recency.

animal behavior and cognition↗