Atencio, L. | Search bioRxiv

bioRxiv2025

First record of Aedes albopictus in the department of Magdalena, North of Colombia: implications for arboviral disease transmission

Aedes albopictus is widely distributed throughout the world. It was introduced into the Americas in 1985 and is considered a vector for arboviruses such as dengue. The species has been reported in fifteen departments of the country. With this brief communication, we aim to report the finding of Ae. albopictus in five municipalities in the department of Magdalena. Between June and November 2025, adult mosquitoes were collected and breeding sites were inspected in the five municipalities. Both the collected adults and larvae were identified at the entomology unit of the Public Health Laboratory of the Department of Magdalena and confirmed by the entomology laboratory of the National Institute of Health. Larvae and adults of Ae. albopictus were found in all five municipalities. The detection of Ae. albopictus in five municipalities in the department of Magdalena highlights the importance of strengthening continuous entomological surveillance strategies at the municipal and departmental levels in the country, especially in Magdalena and the surrounding municipalities.

zoology↗

bioRxiv2020

Differential gene expression in the interactome of the Human Dopamine transporter in the context of Parkinson's disease

BackgroundThe human dopamine transporter is the main regulator of dopamine tone and an intricate network exists to regulate the expression, conformation, and kinetics of the hDAT. hDAT dysfunction is directly related to Parkinsons disease. The objective of this work is to evaluate the differential gene expression in the interactome of the Dopamine transporter in the context of Parkinsons disease. MethodsTo do this, we evaluated hDAT interaction data in string-db, mint.bio, IntAct, reactome, hprd and BioGRID, subsequently, data was obtained from the differential gene expression of mRNA and miRNAs for this hDAT interactome in the context of PD. ResultsThe analysis of the differential expression changes of genes of the hDAT interactome in tissues of patients with PD compared with tissues of individuals without PD, allowed to identify an expression pattern of 32 components of the hDAT interactome, of which 31 presented a negative change proportion in PD. ConclusionsWe found a total of 90 miRNAs that could regulate the expression of 27 components of the hDAT interactome, at the same time, 39 components of the hDAT interactome may participate in 40 metabolic pathways. Together, these findings show a systematic effect on the hDAT-mediated dopamine internalization process in patients with Parkinsons, which would contribute to a greater susceptibility to neuronal oxidative stress in PD patients.

bioinformatics↗