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Anders Eklund

Publications and source records attributed to Anders Eklund.

2 recordsLinked to original sources

BIDS Apps: Improving ease of use, accessibility and reproducibility of neuroimaging data analysis methods

The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness richness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms.\n\nAuthor SummaryMagnetic Resonance Imaging (MRI) is a non-invasive way to measure human brain structure and activity that has been used for over 25 years. There are thousands MRI studies performed every year generating a substantial amount of data. At the same time, many new data analysis methods are being developed every year. The potential of using new analysis methods on the variety of existing and newly acquired data is hindered by difficulties in software deployment and lack of support for standardized input data. Here we propose to use container technology to make deployment of a wide range of data analysis techniques easy. In addition, we adapt the existing data analysis tools to interface with data organized in a standardized way. We hope that this approach will enable researchers to access a wider range of methods when analyzing their data which will lead to accelerated progress in human neuroscience.

Neuroscience

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis

1. Introduction 1. Introduction 2. Material and methods 3. Results 4. Discussion 6 References Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system (CNS) [1], with a largely unknown aetiology. International efforts have defined over 100 genetic loci modifying the risk for MS [2]. However, these genes only explain a fraction of the disease risk, suggesting an important contributory role of environmental factors [3]. One of the most established environmental risk factors for MS is cigarette smoking, with an estimated odds ratio (OR) of 1.51 for daily smokers compared to nonsmokers [4]. This risk factor is also shared with other autoimmune diseases, including rheumatoid arthritis (RA), where a risk increase of a similar magnitu ...

Immunology