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Biology subjects

Ali, A. F.

Publications and source records attributed to Ali, A. F..

3 recordsLinked to original sources

A Two-Fluid Model of Brain Dynamics

We develop a theoretical proposal linking vacuum stability and brain dynamics through superconductivity-inspired coherence, symmetry reduction, and the thermodynamic stabilization of low-entropy regimes. We take an unbroken SU(3) structure as a candidate stable residue of the low-temperature vacuum. At the neural level, we formulate a coarse-grained analog in which a two-fluid model with dissipative and coherence-supporting components describes brain dynamics. Specifically, the coherence-supporting component is proposed as a possible basis for the efficient binding and integration required to sustain a stable, unified conscious state. The proposal offers a common geometric language for relating physics and neuroscience with falsifiable signatures in coherence and state-dependent transitions. The main technical contribution is a computational algebraic model of conscious-state dynamics, where neural data are mapped to reconstructed state trajectories. Effective generators are inferred from those trajectories, and the two-fluid split is tested as a Cartan-root decomposition of su(3), with a rank-two commuting sector for coherence-preserving balance and six root directions for state transitions. This structure can be tested on neural data and contrasted with alternative dynamical models.

neuroscience↗

Proteomic characterization of major fish allergy responsive protein parvalbumins in Hilsa (Tenualosa ilisha): A commercially important fish in Southeast Asia

The protein parvalbumin (PRV)-beta (PRVB) is the primary cause of food allergies to bony fish. Although PRVB is a well-characterized protein in many bony fishes, little is known about the Hilsa, an anadromous fish with great economic importance and predominantly found in Southeast Asia. In this study, we characterized the Hilsa PRV utilizing various proteomic approaches in response to two major riverine habitats and developmental stages. Unique peptide sets corresponding to three PRV isoforms were identified in Hilsa muscle tissues. Label-free quantitative proteomic analysis coupled with ELISA revealed higher levels of PRVB in young fish compared to adults, irrespective of their riverine habitats. A comparative quantitative analysis of PRVB further demonstrated that Hilsa had less PRVB than other commonly consumed freshwater fish species. Multiple reaction monitoring (MRM)-based targeted proteomic approach showed the potential of PRV as a marker protein for allergen quantitation and authenticating the presence of Hilsa in a complex freshwater fish mixture. Our findings collectively offer fundamental knowledge on Hilsa PRVs for further investigation on the food safety and quality evaluation of Hilsa fish.

biochemistry↗

Cotton Microbiome Profiling and Cotton Leaf Curl Disease (CLCuD) Suppression through Microbial Consortia associated with Gossypium arboreum

The failure of breeding strategies has caused scientists to shift to other means where the new approach involves exploring the microbiome to modulate plant defense mechanisms against CLCuD. The cotton microbiome of CLCuD-resistant varieties may harbor a multitude of bacterial genera that significantly contribute to disease resistance and provide information on metabolic pathways that differ between the susceptible and resistant varieties. The current study aimed to explore the microbiome of CLCuD-susceptible Gossypium hirsutum and CLCuD-resistant Gossypium arboreum. Microbial community surveys performed using 16S rRNA gene amplification revealed that Pseudomonas inhabited the rhizosphere while Bacillus was predominantly found in the phyllosphere of CLCuV-tolerant G. arboreum. The study was done for the leaf endophyte, leaf epiphyte, rhizosphere, and root endophyte of the two cotton species. Furthermore, our disease incidence assay using pot experiments has revealed mechanistic insights through salicylic acid-producing Serratia spp. and Fictibacillus spp. isolated from CLCuD-resistant G. arboreum, which exhibited viral disease suppression and induced systemic resistance in CLCuD susceptible G. hirsutum.

plant biology↗