Biology subjects

Adewuyi, H. A.

Publications and source records attributed to Adewuyi, H. A..

3 recordsLinked to original sources

bioRxiv2025

Phytochemical Analysis And Pharmacological Effects Of Gongronema Latifolium Extracts On Tamoxifen-Induced Toxicity In Wistar Rats

BackgroundTamoxifen, a widely used anti-estrogen medication, is known to induce oxidative stress, hepatic toxicity, and hematological disorders. Gongronem alatifolium, a tropical plant, has been traditionally used in folk medicine to treat various ailments. This study aimed to investigate the phytochemical analysis and pharmacological effects of Gongronema latifolium extracts on tamoxifen-induced toxicity in rats. MethodsThe study employed a randomized controlled trial design, where rats were divided into six groups of six (6) rats each. Group one were administered with distilled water (1 mL), group two tamoxifen-treated (20 mg/kg), group three tamoxifen + zinc sulfate (100 mg/kg), group four tamoxifen + Gongronema latifolium methanol extract (200 mg/kg), group five tamoxifen + Gongronema latifolium ethanol extract (200 mg/kg), and group six tamoxifen + zinc sulfate + Gongronema latifolium methanol extract 100 mg/kg + 200 mg/kg. Phytochemical analysis was conducted using standard methods. Oxidative stress markers, biochemical parameters, and hematological parameters were measured using standard assays. ResultsThe results of the study revealed significant reduction in MDA levels and improved SOD activities, increases in the total protein and reduced ALT and AST activities, reduced total cholesterol and triglycerides levels, but increases HDL level, reduced creatinine and urea levels, while RBC and Hb levels were significantly improved. Conclusion: This study provides new insights into the pharmacological effects of Gongronema latifolium extracts and highlights their potential as a natural remedy for reducing tamoxifen toxicity. The studys findings have significant implications for the development of novel therapeutic strategies for reducing tamoxifen toxicity.

pharmacology and toxicology↗

bioRxiv2025

Protective Effects of Zingiber officinale Juice Extract Against Cisplatin-Induced Toxicity: Oxidative Stress, Biochemical, Hematological, And Reproductive Hormone Changes in Wistar Rats

Cisplatin, a widely used chemotherapeutic agent, is associated with significant toxicity. Zingiberofficinale, commonly known as ginger, has antioxidant and anti-inflammatory properties.The present study was conducted to investigate the protective effects of Zingiberofficinale juice against cisplatin-induced toxicity in Wistar rats.Rats were divided into control group, cisplatin induced (7 mg/kg), Zingiberofficinale juice (500 mg/kg), and combination groups. Biochemical, hematological, oxidative stress, inflammatory, and apoptotic markers were assessed using standard protocol.In this study, it was observed that Cisplatin administration significantly increased liver and kidney weights, altered biochemical parameters (ALT, AST, ALP, bilirubin, and creatinine), and induced oxidative stress (MDA), inflammation (TNF-, IL-1{beta}, IL-6), and apoptosis (caspase-3, Bax). In contrast, Zingiberofficinale juice supplementation significantly reduced liver and kidney weights, improved biochemical parameters, decreased oxidative stress and inflammatory markers, inhibited apoptotic markers, and enhanced antioxidant defenses (GSH, SOD, CAT). Notably, the combination of Zingiberofficinale juice and cisplatin showed improved biochemical, hematological, oxidative stress, inflammatory, and apoptotic markers compared to cisplatin alone, demonstrating the protective effects of Zingiberofficinale juice against cisplatin-induced toxicity.Zingiberofficinale juice exhibits protective effects against cisplatin-induced toxicity in Wistar rats, suggesting its potential as an adjunctive therapy to reduce chemotherapy-related side effects.

cancer biology↗

bioRxiv2025

Ameliorative Effects of Brideliaferruginea Extracts on Cadmium Chloride-Induced Reproductive Hormone Imbalance, Oxidative Stress, Hepatorenal Damage, Hematological Disorders, and Acute Toxicity in Wistar Rats

BackgroundCadmium chloride is a toxic heavy metal that can cause oxidative stress, damage to organs, and disrupt hormonal balance. Brideliaferruginea is a plant with antioxidant and free radical-scavenging properties. The aim of this study was to investigate the protective effects of Brideliaferruginea extract against cadmium chloride-induced toxicity in rats. MethodsThis study used a randomized controlled design, with 36 rats divided into 6 groups. The rats were treated with cadmium chloride, Brideliaferruginea extract, or a combination of both. The study employed various assay methods, including acute toxicity test, reproductive hormone marker assays, oxidative stress marker assays, hepatic marker assays, and hematological parameter assays. Main findingsThe results showed that cadmium chloride induced significant acute toxicity, as evidenced by 33.33% mortality rate and significant body weight loss (-15.67 {+/-} 3.33 g), whereas co-treatment with BFE (100 and 200 mg/kg) reduced mortality to 0% and reversed body weight loss to a gain of 10.00 {+/-} 2.50g and 20.00 {+/-} 2.50g, respectively. CdCl2 group had significantly lower testosterone, LH, and FSH levels compared to the control group (p < 0.05), significantly higher MDA levels and lower SOD and CAT levels compared to the control group (p < 0.05).significantly higherALT, AST, and ALP levels compared to the control group (p < 0.05), and significantly lower Hb, PCV, WBC, and RBC levels compared to the control group (p < 0.05) respectively. Co-administration of Brideliaferruginea extract with CdCl2 significantly improved reproductive hormone markers, reduced MDA levels and improved SOD and CAT levels in a dose-dependent manner (p < 0.05). Additionally, ALT, AST, and ALP levels were significantly reduced in a dose-dependent manner (p < 0.05), hematological parameters significantly improved in Hb, PCV, WBC, and RBC levels in a dose-dependent manner (p < 0.05). The highest dose of Brideliaferruginea extract (200 mg/kg) showed the most significant improvement in all parameters (p < 0.01). ImplicationsThis study suggests that Brideliaferruginea extract may be a useful therapeutic agent against heavy metal toxicity. The findings have implications for the development of novel treatments for heavy metal poisoning and highlight the potential of Brideliaferruginea extract as a natural remedy for heavy metal toxicity.

pharmacology and toxicology↗